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Tchem
RIPK1
Receptor-interacting serine/threonine-protein kinase 1

Protein Summary
Description
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IK ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259808
  • ENSP00000259808
  • ENSG00000137275
  • ENST00000380409
  • ENSP00000369773

Symbol
  • RIP
  • RIP1
  • RIP
  • RIP1
  • IMD57
  • RIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.99
virus perturbation
0.98
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 702.07   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 543   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 702.07   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 543   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 153
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1