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Tbio
RIOX2
Ribosomal oxygenase 2

Protein Summary
Description
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333396
  • ENSP00000328251
  • ENSG00000170854
  • ENST00000360258
  • ENSP00000353395
  • ENST00000394198
  • ENSP00000377748
  • ENST00000514314
  • ENSP00000424955

Symbol
  • MDIG
  • MINA
  • MINA53
  • NO52
  • ROX
  • MDIG
  • MINA
  • NO52
  • JMJD10
  • MINA53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.31   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.31   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
RBM18
Tdark
Novelty:  5.77641942
p_int:  0.999368593
p_ni:  0.000631407
Score:  0.187
Data Source:  BioPlex,STRINGDB
HIRIP3
Tdark
Novelty:  0.34456295
p_int:  0.998933528
p_ni:  0.001066421
p_wrong:  5.1e-8
Data Source:  BioPlex
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.99813354
p_ni:  0.00186646
Score:  0.499
Data Source:  BioPlex,STRINGDB
C1orf174
Tdark
Novelty:  4.20172485
p_int:  0.995605244
p_ni:  0.004394754
p_wrong:  2e-9
Data Source:  BioPlex
UIMC1
Tbio
Novelty:  0.02039732
p_int:  0.992072197
p_ni:  0.007927803
Score:  0.209
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.984783106
p_ni:  0.015216894
Data Source:  BioPlex
POLL
Tbio
Family:  Enzyme
Novelty:  0.00244645
p_int:  0.970756155
p_ni:  0.029243845
Score:  0.167
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.968967638
p_ni:  0.03103236
p_wrong:  2e-9
Data Source:  BioPlex
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.958417695
p_ni:  0.041574256
p_wrong:  0.000008049
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.936938083
p_ni:  0.063059682
p_wrong:  0.000002235
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal oxygenase 2
VGNC:2046
460541
Mouse
MGI:1914264
67014
Dog
ribosomal oxygenase 2
VGNC:45593
478533
Horse
ribosomal oxygenase 2
VGNC:22397
100072544
Cow
ribosomal oxygenase 2
VGNC:33980
540466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal oxygenase 2
Mouse
Dog
ribosomal oxygenase 2
Horse
ribosomal oxygenase 2
Cow
ribosomal oxygenase 2
Publication Statistics
PubMed Score 41.31
PubMed score by year
PubTator Score 54.89
PubTator score by year
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Related Publications
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PMID
Year
Title