Pharos : Target Details

Tchem

Protein Summary

Description

Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for th ...more

Uniprot Accession IDs

Gene Name

RIOK1

Ensembl ID

ENST00000379834
ENSP00000369162
ENSG00000124784

Symbol

RIO1
RIO1
AD034
RRP10
bA288G3.1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98

molecular function	0.9

histone modification site profile	0.87

small molecule	0.8

transcription factor binding site profile	0.77

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.07 (req: < 5)

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Gene RIFs: 7 (req: <= 3)

View Gene RIFs

Antibodies: 183 (req: <= 50)

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Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.07 (req: >= 5)

Gene RIFs: 7 (req: > 3)

Antibodies: 183 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

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Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

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Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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ProtVista Viewer

Related Tools (6)

Dark Kinase Knowledgebase

The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.

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ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Go To Tool

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

nintedanib

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

lestaurtinib

Protein-Protein Interactions (207)

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1 – 10 of 207

See Interactions on String-DB

EPB41L3

Tbio

Novelty: 0.00915217

p_int: 0.999995974

p_ni: 0.000004026

Data Source: BioPlex

LSM6

Tbio

Novelty: 0.09507671

p_int: 0.99998531

p_ni: 0.00001469

Data Source: BioPlex

COPRS

Tbio

Novelty: 0.03545787

p_int: 0.999960062

p_ni: 0.000039938

Score: 0.586

Data Source: BioPlex,STRINGDB

GAR1

Tbio

Novelty: 0.26091307

p_int: 0.99991938

p_ni: 0.000080619

p_wrong: 1e-9

Score: 0.398

Data Source: BioPlex,STRINGDB

TINAGL1

Tbio

Novelty: 0.05578199

p_int: 0.999879025

p_ni: 0.000120975

Score: 0.198

Data Source: BioPlex,STRINGDB

SNRPB

Tbio

Novelty: 0.01503535

p_int: 0.999818595

p_ni: 0.000181405

Data Source: BioPlex

PPP1R14A

Tbio

Family: Enzyme

Novelty: 0.00231198

p_int: 0.999226335

p_ni: 0.000773657

p_wrong: 9e-9

Data Source: BioPlex

CHTOP

Tbio

Novelty: 0.04170391

p_int: 0.999033035

p_ni: 0.000966949

p_wrong: 1.6e-8

Data Source: BioPlex

SNRPN

Tbio

Novelty: 0.002157

p_int: 0.99861159

p_ni: 0.00138841

Data Source: BioPlex

RPS2

Tbio

Novelty: 0.00412313

p_int: 0.995627939

p_ni: 0.004372061

Score: 0.986

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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Items per page:

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226

Reactome	Metabolism of RNA	686 targets	R-HSA-8953854

Reactome	rRNA processing	217 targets	R-HSA-72312

Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226

Metabolism of RNA	686 targets	R-HSA-8953854

rRNA processing	217 targets	R-HSA-72312

rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (4)

Components (4)

Processes (3)

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Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

hydrolase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

protein serine/threonine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
age at onset	EFO_0004847	1	1	0	6	35

Myopia	HP_0000545	1	1	0	6	35

refractive error measurement	EFO_0007814	1	1	0	6	35

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Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
age at onset	EFO_0004847	0	6	35

Myopia	HP_0000545	0	6	35

refractive error measurement	EFO_0007814	0	6	35

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
3D-structure

ATP-binding

Complete proteome

Cytoplasm

Direct protein sequencing

Hydrolase

Kinase

Magnesium

Metal-binding

Nucleotide-binding

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID
Chimp	RIO kinase 1	VGNC:11207	471847

Macaque	RIO kinase 1		694461

Mouse	RIO kinase 1	MGI:1918590	71340

Rat	RIO kinase 1	RGD:1306086	291061

Dog	RIO kinase 1		478713

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RIO kinase 1

Macaque	RIO kinase 1

Mouse	RIO kinase 1

Rat	RIO kinase 1

Dog	RIO kinase 1

Publication Statistics

PubMed Score 50.07

PubMed score by year

PubTator Score 8.03

PubTator score by year

Patents

Patents by year

Related Publications

Text Mined References (15)

GeneRif Annotations (7)

Items per page:

0 of 0

PMID	Year	Title