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Tbio
RINT1
RAD50-interacting protein 1

Protein Summary
Description
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257700
  • ENSP00000257700
  • ENSG00000135249

Symbol
  • RINT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
transcription factor binding site profile
0.73
cell line
0.61
tissue
0.6
cell type or tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.63   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.63   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
SCFD2
Tdark
Novelty:  0.38252131
p_int:  1
Score:  0.96
Data Source:  BioPlex,STRINGDB
USE1
Tbio
Novelty:  0.00904756
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NBAS
Tbio
Novelty:  0.01187862
p_int:  0.999999956
p_ni:  4.4e-8
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
C19orf25
Tdark
Novelty:  8.61479932
p_int:  0.9999991
p_ni:  9e-7
Score:  0.969
Data Source:  BioPlex,STRINGDB
SPAG5
Tbio
Novelty:  0.02392116
p_int:  0.999984763
p_ni:  0.000015237
Data Source:  BioPlex
ZW10
Tbio
Novelty:  0.01680538
p_int:  0.999973445
p_ni:  0.000026555
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.999943075
p_ni:  0.000056925
Score:  0.991
Data Source:  BioPlex,STRINGDB
BNIP1
Tbio
Novelty:  0.04601895
p_int:  0.999864016
p_ni:  0.000135974
p_wrong:  9e-9
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999708298
p_ni:  0.000291702
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.996988423
p_ni:  0.003011577
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD50 interactor 1
VGNC:4495
743241
Macaque
RAD50 interactor 1
698414
Mouse
MGI:1916233
72772
Rat
RGD:1560433
296750
Dog
RAD50 interactor 1
VGNC:45591
475893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD50 interactor 1
Macaque
RAD50 interactor 1
Mouse
Rat
Dog
RAD50 interactor 1
Publication Statistics
PubMed Score 23.63
PubMed score by year
PubTator Score 15.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title