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Tbio
RING1
E3 ubiquitin-protein ligase RING1

Protein Summary
Description
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc fin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374656
  • ENSP00000363787
  • ENSG00000204227
  • ENST00000383212
  • ENSP00000372699
  • ENSG00000206287
  • ENST00000415941
  • ENSP00000412190
  • ENSG00000226788
  • ENST00000427374
  • ENSP00000400572
  • ENSG00000231115
  • ENST00000430233
  • ENSP00000396271
  • ENSG00000228520
  • ENST00000436128
  • ENSP00000396439
  • ENSG00000235107

Symbol
  • RNF1
  • RNF1
  • RING1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.87
cell type or tissue
0.8
cellular component
0.8
tissue sample
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.12   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 538   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.12   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 538   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (245)
PCGF2
Tbio
Novelty:  0.02148755
p_int:  0.999994194
p_ni:  0.000005806
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.999975692
p_ni:  0.000024308
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999903759
p_ni:  0.000096241
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
FGA
Tbio
Novelty:  0.00107227
p_int:  0.99960761
p_ni:  0.00039239
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
FGG
Tbio
Novelty:  0.00404457
p_int:  0.999228455
p_ni:  0.00076754
p_wrong:  0.000004005
Score:  0.167
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.999165458
p_ni:  0.000834537
p_wrong:  5e-9
Data Source:  BioPlex
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.998635721
p_ni:  0.001364279
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PHC1
Tbio
Novelty:  0.01530622
p_int:  0.99779148
p_ni:  0.00220852
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.996714096
p_ni:  0.003285904
Score:  0.971
Data Source:  BioPlex,STRINGDB
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
p_int:  0.995771206
p_ni:  0.004228794
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (93)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (70)
Items per page:
1 – 5 of 70
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
76.5
2
2
0
1.1
76.5
2
2
0
1.1
76.5
2
2
0
1.1
76.5
2
2
0
1.1
76.5
Items per page:
1 – 5 of 70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
76.5
0
1.1
76.5
0
1.1
76.5
0
1.1
76.5
0
1.1
76.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 1
VGNC:11205
462604
Macaque
ring finger protein 1
718137
Mouse
MGI:1101770
19763
Rat
RGD:3576
309626
Dog
ring finger protein 1
VGNC:45589
607905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 1
Macaque
ring finger protein 1
Mouse
Rat
Dog
ring finger protein 1
Publication Statistics
PubMed Score 116.12
PubMed score by year
PubTator Score 105.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title