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Tbio
RIMS2
Regulating synaptic membrane exocytosis protein 2

Protein Summary
Description
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262231
  • ENSP00000262231
  • ENSG00000176406
  • ENST00000339750
  • ENSP00000342051
  • ENST00000504942
  • ENSP00000427018
  • ENST00000507740
  • ENSP00000423559

Symbol
  • KIAA0751
  • RAB3IP3
  • RIM2
  • OBOE
  • RIM2
  • RAB3IP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.76
trait
0.75
disease perturbation
0.74
interacting protein
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0