Tbio RIMS1 Regulating synaptic membrane exocytosis protein 1

Protein Summary

Description

Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q86UR5
• A7MBN6
• B7Z2M0
• B7Z2Q9
• B7Z3S3
• B7Z6S2
• E7EX08
• E9PCB7
• E9PCZ1
• E9PF48
• E9PHF5
• E9PHR1
• O15048
• Q5JY21
• Q5JY25
• Q5SZK1
• Q8TDY9
• Q8TDZ5
• Q9HBA1
• Q9HBA2
• Q9HBA3
• Q9HBA4
• Q9HBA5
• Q9HBA6

Gene Name

• RIMS1

Ensembl ID

• ENST00000264839
• ENSP00000264839
• ENSG00000079841
• ENST00000401910
• ENSP00000385649
• ENST00000414192
• ENSP00000402273
• ENST00000425662
• ENSP00000411235
• ENST00000491071
• ENSP00000430101
• ENST00000517827
• ENSP00000428367
• ENST00000517960
• ENSP00000429959
• ENST00000518273
• ENSP00000430408
• ENST00000520567
• ENSP00000430502
• ENST00000521978
• ENSP00000428417
• ENST00000522291
• ENSP00000430932
• ENST00000523963
• ENSP00000428328

Symbol

• KIAA0340
• RAB3IP2
• RIM1
• RIM
• RIM1
• CORD7
• RAB3IP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
microRNA	0.89
protein domain	0.85
interacting protein	0.77
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulating Synaptic Membrane Exocytosis Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulating Synaptic Membrane Exocytosis Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.26   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.26   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0