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Tbio
RILP
Rab-interacting lysosomal protein

Protein Summary
Description
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301336
  • ENSP00000301336
  • ENSG00000167705
  • ENST00000622136
  • ENSP00000481849
  • ENSG00000274145

Symbol
  • PP10141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
transcription factor binding site profile
0.68
cell type or tissue
0.67
histone modification site profile
0.54
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
RAB7A
Tchem
Family:  Enzyme
Novelty:  0.00192702
Score:  0.998
Data Source:  Reactome,STRINGDB
RAB7B
Tbio
Family:  Enzyme
Novelty:  0.00207354
Score:  0.993
Data Source:  STRINGDB
OSBPL1A
Tbio
Novelty:  0.12951159
Score:  0.956
Data Source:  Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.944
Data Source:  STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
Score:  0.929
Data Source:  STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
Score:  0.929
Data Source:  STRINGDB
SPTBN2
Tbio
Novelty:  0.01183066
Score:  0.925
Data Source:  STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
Score:  0.922
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.921
Data Source:  STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
5
6
96.9
serum albumin measurement
3
5
6
96.9
sex hormone-binding globulin measurement
6
3
8
96.6
sex hormone-binding globulin measurement
6
3
8
96.6
alkaline phosphatase measurement
2
2
2
12
92.3
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
96.9
serum albumin measurement
6
96.9
sex hormone-binding globulin measurement
8
96.6
sex hormone-binding globulin measurement
8
96.6
alkaline phosphatase measurement
2
12
92.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Rab interacting lysosomal protein
701798
Mouse
MGI:2144271
280408
Rat
RGD:1307691
287531
Dog
Rab interacting lysosomal protein
VGNC:45576
480649
Horse
Rab interacting lysosomal protein [Source:HGNC Symbol;Acc:HGNC:30266]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Rab interacting lysosomal protein
Mouse
Rat
Dog
Rab interacting lysosomal protein
Horse
Rab interacting lysosomal protein [Source:HGNC Symbol;Acc:HGNC:30266]
Publication Statistics
PubMed Score 16.00
PubMed score by year
PubTator Score 35.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title