Tbio RIDA 2-iminobutanoate/2-iminopropanoate deaminase

Protein Summary

Description

Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. May also function as an endoribonuclease, cleaving mRNA phosphodiester bonds of single-stranded RNA (By similarity). Thereby, may inhibit protein translation (PubMed:8973653).

Uniprot Accession IDs

• P52758
• Q6FHU9
• Q6IBG0

Gene Name

• RIDA

Ensembl ID

• ENST00000254878
• ENSP00000254878
• ENSG00000132541

Symbol

• HRSP12
• PSP
• P14.5
• UK114
• HRSP12
• hp14.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.33   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.33   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (58)

Explore Interacting Targets

1 – 10 of 58

• See Interactions on String-DB

ACOX1

Tchem

Family:  Enzyme

Novelty:  0.00473427

p_int:  0.99932713

p_ni:  0.000672869

Score:  0.206

Data Source:  BioPlex,STRINGDB

CARM1

Tchem

Family:  Epigenetic

Novelty:  0.00623937

p_int:  0.99849296

p_ni:  0.00150704

Score:  0.198

Data Source:  BioPlex,STRINGDB

UBB

Tbio

Novelty:  0.00661254

p_int:  0.996694543

p_ni:  0.003305457

Data Source:  BioPlex

OGA

Tchem

Family:  Enzyme

Novelty:  0.00035723

p_int:  0.972138262

p_ni:  0.027861738

Score:  0.19

Data Source:  BioPlex,STRINGDB

SRPRB

Tbio

Novelty:  0.04735362

Score:  0.818

Data Source:  STRINGDB

SUGP1

Tbio

Novelty:  0.00434166

Score:  0.816

Data Source:  STRINGDB

RBMS1

Tbio

Novelty:  0.00520684

Score:  0.813

Data Source:  STRINGDB

SCO2

Tbio

Novelty:  0.00680753

Score:  0.811

Data Source:  STRINGDB

PQBP1

Tbio

Novelty:  0.01631148

Score:  0.806

Data Source:  STRINGDB

NDUFA7

Tclin

Family:  Enzyme

Novelty:  0.16417588

Score:  0.794

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism (R-HSA-1430728)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Threonine catabolism	5 targets	R-HSA-8849175

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Threonine catabolism	5 targets	R-HSA-8849175

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (8)

Components (6)

Processes (10)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
deaminase activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
endoribonuclease activity, producing 3'-phosphomonoesters	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
long-chain fatty acid binding	Inferred from Electronic Annotation (IEA)	Ensembl
platinum binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein homodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
transition metal ion binding	Inferred from Electronic Annotation (IEA)	Ensembl
xenon atom binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Mitochondrion
Nucleus
Peroxisome
Phosphoprotein

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	reactive intermediate imine deaminase A homolog	VGNC:6673	740532
Mouse	reactive intermediate imine deaminase A homolog	MGI:1095401	15473
Rat	reactive intermediate imine deaminase A homolog	RGD:70940	65151
Dog	reactive intermediate imine deaminase A homolog		475043
Horse	ribonuclease UK114		100147364

Species	Name	OMA	EggNOG	Inparanoid
Chimp	reactive intermediate imine deaminase A homolog
Mouse	reactive intermediate imine deaminase A homolog
Rat	reactive intermediate imine deaminase A homolog
Dog	reactive intermediate imine deaminase A homolog
Horse	ribonuclease UK114

Publication Statistics

PubMed Score 58.33

PubMed score by year

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PubTator Score 27.81

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (3)

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10

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PMID	Year	Title