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Tbio
RIC8A
Synembryn-A

Protein Summary
Description
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325207
  • ENSP00000325941
  • ENSG00000177963
  • ENST00000526104
  • ENSP00000432008
  • ENST00000527696
  • ENSP00000434833

Symbol
  • RIC8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.84
histone modification site profile
0.82
interacting protein
0.72
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.88   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.88   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.999997809
p_ni:  0.000002191
Score:  0.979
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.999896106
p_ni:  0.000103894
Score:  0.832
Data Source:  BioPlex,STRINGDB
SPAG5
Tbio
Novelty:  0.02392116
p_int:  0.999890066
p_ni:  0.000109934
Data Source:  BioPlex
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.998277052
p_ni:  0.001722948
Score:  0.696
Data Source:  BioPlex,STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.997792235
p_ni:  0.002203926
p_wrong:  0.000003839
Score:  0.784
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.997767332
p_ni:  0.002232668
Score:  0.774
Data Source:  BioPlex,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.997683624
p_ni:  0.002316376
Score:  0.699
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.997617416
p_ni:  0.002382584
Score:  0.82
Data Source:  BioPlex,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.997122902
p_ni:  0.002875317
p_wrong:  0.000001781
Score:  0.82
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.994483584
p_ni:  0.005516416
Score:  0.827
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
7
10
99.6
platelet count
5
5
5
4.7
98.9
alkaline phosphatase measurement
3
3
3
17.9
96.7
monocyte percentage of leukocytes
2
3
4
96.2
neutrophil count
3
2
4
95.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
99.6
platelet count
5
4.7
98.9
alkaline phosphatase measurement
3
17.9
96.7
monocyte percentage of leukocytes
4
96.2
neutrophil count
4
95.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RIC8 guanine nucleotide exchange factor A
VGNC:1022
466300
Macaque
RIC8 guanine nucleotide exchange factor A
696720
Mouse
MGI:2141866
101489
Rat
RGD:727957
293614
Dog
RIC8 guanine nucleotide exchange factor A
VGNC:45572
475932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RIC8 guanine nucleotide exchange factor A
Macaque
RIC8 guanine nucleotide exchange factor A
Mouse
Rat
Dog
RIC8 guanine nucleotide exchange factor A
Publication Statistics
PubMed Score 73.88
PubMed score by year
PubTator Score 31.96
PubTator score by year
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Related Publications
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PMID
Year
Title