Protein Summary
Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- ENST00000309737
- ENSP00000308820
- ENSG00000166405
- ENST00000335425
- ENSP00000333988
- ENST00000343202
- ENSP00000344904
- ENST00000419822
- ENSP00000404415
- ENST00000425599
- ENSP00000395320
- AYST720
- PRO1385
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.72 | ||
cellular component | 0.64 | ||
histone modification site profile | 0.64 | ||
tissue | 0.53 | ||
tissue sample | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.65 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 72 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.65 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 72 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (66)
TAPT1
Novelty: 0.12057711
p_int: 0.999997822
p_ni: 0.000002165
p_wrong: 1.3e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
PHB2
Novelty: 0.00458856
p_int: 0.999636197
p_ni: 0.000363803
Score: 0.221
Data Source: BioPlex,STRINGDB
PHB
Novelty: 0.00178383
p_int: 0.999632845
p_ni: 0.000367155
Score: 0.221
Data Source: BioPlex,STRINGDB
ATP9A
Family: Transporter
Novelty: 0.15755352
p_int: 0.99287452
p_ni: 0.007124356
p_wrong: 0.000001124
Data Source: BioPlex
SLC30A6
Family: Transporter
Novelty: 0.06083299
p_int: 0.992471728
p_ni: 0.007528263
p_wrong: 9e-9
Score: 0.486
Data Source: BioPlex,STRINGDB
SLC30A5
Family: Transporter
Novelty: 0.02432633
p_int: 0.973678778
p_ni: 0.026320965
p_wrong: 2.57e-7
Score: 0.479
Data Source: BioPlex,STRINGDB
ERLIN2
Novelty: 0.04060163
p_int: 0.956948274
p_ni: 0.043051726
Score: 0.175
Data Source: BioPlex,STRINGDB
RMND1
Novelty: 0.06181833
p_int: 0.948691745
p_ni: 0.05130817
p_wrong: 8.6e-8
Data Source: BioPlex
USP22
Family: Enzyme
Novelty: 0.01416662
p_int: 0.94565879
p_ni: 0.052516574
p_wrong: 0.001824636
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.3 | 78.2 | |||||
parental genotype effect measurement | 1 | 1 | 1 | 73.7 | |||||
birth weight | 1 | 1 | 1 | 73.7 | |||||
age-related hearing impairment | 1 | 1 | 0 | 6.7 | 49.5 | ||||
body height | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 78.2 | |||||
parental genotype effect measurement | 1 | 73.7 | |||||
birth weight | 1 | 73.7 | |||||
age-related hearing impairment | 0 | 6.7 | 49.5 | ||||
body height | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RIC3 acetylcholine receptor chaperone | VGNC:1023 | 451009 | |||||
Macaque | RIC3 acetylcholine receptor chaperone | 706162 | ||||||
Mouse | MGI:2443887 | 320360 | ||||||
Rat | RGD:1588939 | 687147 | ||||||
Dog | RIC3 acetylcholine receptor chaperone | VGNC:45571 | 611343 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RIC3 acetylcholine receptor chaperone | |||||
Macaque | RIC3 acetylcholine receptor chaperone | |||||
Mouse | ||||||
Rat | ||||||
Dog | RIC3 acetylcholine receptor chaperone | |||||
Publication Statistics
PubMed Score 69.65
PubMed score by year
PubTator Score 32.20
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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