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Tbio
RIC3
Protein RIC-3

Protein Summary
Description
Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309737
  • ENSP00000308820
  • ENSG00000166405
  • ENST00000335425
  • ENSP00000333988
  • ENST00000343202
  • ENSP00000344904
  • ENST00000419822
  • ENSP00000404415
  • ENST00000425599
  • ENSP00000395320

Symbol
  • AYST720
  • PRO1385
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.72
cellular component
0.64
histone modification site profile
0.64
tissue
0.53
tissue sample
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.65   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.65   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
TAPT1
Tbio
Novelty:  0.12057711
p_int:  0.999997822
p_ni:  0.000002165
p_wrong:  1.3e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
PHB2
Tbio
Novelty:  0.00458856
p_int:  0.999636197
p_ni:  0.000363803
Score:  0.221
Data Source:  BioPlex,STRINGDB
PHB
Tbio
Novelty:  0.00178383
p_int:  0.999632845
p_ni:  0.000367155
Score:  0.221
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.999189839
p_ni:  0.000810161
Data Source:  BioPlex
ATP9A
Tbio
Family:  Transporter
Novelty:  0.15755352
p_int:  0.99287452
p_ni:  0.007124356
p_wrong:  0.000001124
Data Source:  BioPlex
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.992471728
p_ni:  0.007528263
p_wrong:  9e-9
Score:  0.486
Data Source:  BioPlex,STRINGDB
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.973678778
p_ni:  0.026320965
p_wrong:  2.57e-7
Score:  0.479
Data Source:  BioPlex,STRINGDB
ERLIN2
Tbio
Novelty:  0.04060163
p_int:  0.956948274
p_ni:  0.043051726
Score:  0.175
Data Source:  BioPlex,STRINGDB
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.948691745
p_ni:  0.05130817
p_wrong:  8.6e-8
Data Source:  BioPlex
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.94565879
p_ni:  0.052516574
p_wrong:  0.001824636
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.3
78.2
parental genotype effect measurement
1
1
1
73.7
birth weight
1
1
1
73.7
age-related hearing impairment
1
1
0
6.7
49.5
body height
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
78.2
parental genotype effect measurement
1
73.7
birth weight
1
73.7
age-related hearing impairment
0
6.7
49.5
body height
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RIC3 acetylcholine receptor chaperone
VGNC:1023
451009
Macaque
RIC3 acetylcholine receptor chaperone
706162
Mouse
MGI:2443887
320360
Rat
RGD:1588939
687147
Dog
RIC3 acetylcholine receptor chaperone
VGNC:45571
611343
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RIC3 acetylcholine receptor chaperone
Macaque
RIC3 acetylcholine receptor chaperone
Mouse
Rat
Dog
RIC3 acetylcholine receptor chaperone
Publication Statistics
PubMed Score 69.65
PubMed score by year
PubTator Score 32.20
PubTator score by year
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Related Publications
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PMID
Year
Title