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Tbio
RIC1
RAB6A-GEF complex partner protein 1

Protein Summary
Description
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251879
  • ENSP00000251879
  • ENSG00000107036
  • ENST00000414202
  • ENSP00000416696
  • ENST00000418622
  • ENSP00000402240

Symbol
  • CIP150
  • KIAA1432
  • CIP150
  • KIAA1432
  • bA207C16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell line
0.69
microRNA
0.69
hub protein
0.63
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.09   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.09   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
RGP1
Tbio
Novelty:  4
Score:  0.986
Data Source:  Reactome,STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.979
Data Source:  Reactome,STRINGDB
COG8
Tbio
Novelty:  0.02448169
Score:  0.973
Data Source:  STRINGDB
SYS1
Tbio
Novelty:  0.03311919
Score:  0.969
Data Source:  STRINGDB
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
Score:  0.962
Data Source:  Reactome,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
Score:  0.961
Data Source:  STRINGDB
COG3
Tbio
Novelty:  0.02746711
Score:  0.959
Data Source:  STRINGDB
COG5
Tbio
Novelty:  0.04017657
Score:  0.955
Data Source:  STRINGDB
COG7
Tbio
Novelty:  0.07137701
Score:  0.953
Data Source:  STRINGDB
COG1
Tbio
Novelty:  0.0124285
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
11.8
80.5
sex hormone-binding globulin measurement
4
1
4
61
hair color
1
1
0
1.1
46.5
balding measurement
1
1
1
40.7
protein measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
11.8
80.5
sex hormone-binding globulin measurement
4
61
hair color
0
1.1
46.5
balding measurement
1
40.7
protein measurement
1
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RIC1 homolog, RAB6A GEF complex partner 1
VGNC:4848
464982
Mouse
MGI:1924893
226089
Rat
RGD:1310016
309306
Dog
RIC1 homolog, RAB6A GEF complex partner 1
VGNC:45570
484187
Horse
RIC1 homolog, RAB6A GEF complex partner 1
VGNC:22384
100059612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RIC1 homolog, RAB6A GEF complex partner 1
Mouse
Rat
Dog
RIC1 homolog, RAB6A GEF complex partner 1
Horse
RIC1 homolog, RAB6A GEF complex partner 1
Publication Statistics
PubMed Score 24.09
PubMed score by year
PubTator Score 11.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title