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Tbio
RHPN2
Rhophilin-2

Protein Summary
Description
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254260
  • ENSP00000254260
  • ENSG00000131941

Symbol
  • RHOBP
  • P76RBE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.87
transcription factor binding site profile
0.7
small molecule perturbation
0.63
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.66   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.66   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
BCL2L11
Tchem
Novelty:  0.00055914
p_int:  0.999998126
p_ni:  9e-9
p_wrong:  0.000001865
Score:  0.224
Data Source:  BioPlex,STRINGDB
TRMO
Tbio
Novelty:  0.18313621
p_int:  0.993409906
p_ni:  4.5e-8
p_wrong:  0.006590048
Score:  0.359
Data Source:  BioPlex,STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.954
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.953
Data Source:  Reactome,STRINGDB
ROPN1
Tbio
Novelty:  0.05375245
Score:  0.925
Data Source:  STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
Score:  0.906
Data Source:  STRINGDB
MYNN
Tbio
Family:  TF
Novelty:  0.08263054
Score:  0.743
Data Source:  STRINGDB
DPP3
Tbio
Family:  Enzyme
Novelty:  0.00763153
Score:  0.739
Data Source:  STRINGDB
CHMP4A
Tbio
Novelty:  0.01163844
Score:  0.718
Data Source:  STRINGDB
CEP78
Tbio
Novelty:  0.12637977
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (90)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Rhotekin and Rhophilins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Rhotekin and Rhophilins
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
15
99.4
glomerular filtration rate
3
3
4
96.7
alkaline phosphatase measurement
2
2
1
10.4
92.2
5
4
0
1.2
91.4
serum gamma-glutamyl transferase measurement
2
2
2
90.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
15
99.4
glomerular filtration rate
4
96.7
alkaline phosphatase measurement
1
10.4
92.2
0
1.2
91.4
serum gamma-glutamyl transferase measurement
2
90.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhophilin Rho GTPase binding protein 2
VGNC:12077
749937
Macaque
rhophilin Rho GTPase binding protein 2
716602
Mouse
MGI:1289234
52428
Rat
RGD:1308366
308516
Dog
rhophilin Rho GTPase binding protein 2
VGNC:53760
403518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhophilin Rho GTPase binding protein 2
Macaque
rhophilin Rho GTPase binding protein 2
Mouse
Rat
Dog
rhophilin Rho GTPase binding protein 2
Publication Statistics
PubMed Score 22.66
PubMed score by year
PubTator Score 7.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title