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Tbio
RHPN1
Rhophilin-1

Protein Summary
Description
Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289013
  • ENSP00000289013
  • ENSG00000158106

Symbol
  • KIAA1929
  • ODF5
  • RHPN
  • RHOPHILIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell line
0.53
gene perturbation
0.52
metabolite
0.45
cell type or tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
p_int:  0.999999748
p_ni:  2.42e-7
p_wrong:  1e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
PTPN21
Tbio
Family:  Enzyme
Novelty:  0.07773004
p_int:  0.999988297
p_ni:  3.6e-8
p_wrong:  0.000011667
Score:  0.208
Data Source:  BioPlex,STRINGDB
WWC1
Tbio
Novelty:  0.00905646
p_int:  0.999983028
p_ni:  0.00001691
p_wrong:  6.2e-8
Score:  0.299
Data Source:  BioPlex,STRINGDB
WWC2
Tbio
Novelty:  0.13357975
p_int:  0.99997431
p_ni:  0.000019978
p_wrong:  0.000005712
Score:  0.319
Data Source:  BioPlex,STRINGDB
GOLGA2
Tbio
Novelty:  0.00544771
p_int:  0.999966856
p_ni:  0.000033144
Score:  0.159
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999966079
p_ni:  0.000033912
p_wrong:  9e-9
Data Source:  BioPlex
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.999914959
p_ni:  0.000083999
p_wrong:  0.000001042
Score:  0.22
Data Source:  BioPlex,STRINGDB
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.999904633
p_ni:  0.000095366
p_wrong:  1e-9
Data Source:  BioPlex
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.99985101
p_ni:  0.000148971
p_wrong:  1.9e-8
Data Source:  BioPlex
KIF2A
Tbio
Novelty:  0.01463006
p_int:  0.999829311
p_ni:  0.000170643
p_wrong:  4.6e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Rhotekin and Rhophilins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Rhotekin and Rhophilins
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
64.9
BMI-adjusted hip circumference
1
2
2
40.4
body fat percentage
1
1
1
14.2
high density lipoprotein cholesterol measurement
1
1
1
10.1
apolipoprotein A 1 measurement
1
1
1
9.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
64.9
BMI-adjusted hip circumference
2
40.4
body fat percentage
1
14.2
high density lipoprotein cholesterol measurement
1
10.1
apolipoprotein A 1 measurement
1
9.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhophilin Rho GTPase binding protein 1
VGNC:14577
464442
Macaque
rhophilin Rho GTPase binding protein 1
696895
Mouse
MGI:1098783
14787
Rat
RGD:1305688
300030
Dog
rhophilin Rho GTPase binding protein 1
VGNC:45567
482076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhophilin Rho GTPase binding protein 1
Macaque
rhophilin Rho GTPase binding protein 1
Mouse
Rat
Dog
rhophilin Rho GTPase binding protein 1
Publication Statistics
PubMed Score 13.64
PubMed score by year
PubTator Score 6.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title