You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RHOT1
Mitochondrial Rho GTPase 1

Protein Summary
Description
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333942
  • ENSP00000334724
  • ENSG00000126858
  • ENST00000358365
  • ENSP00000351132
  • ENST00000394692
  • ENSP00000378184
  • ENST00000545287
  • ENSP00000439737
  • ENST00000581031
  • ENSP00000464094
  • ENST00000581094
  • ENSP00000462669

Symbol
  • ARHT1
  • ARHT1
  • MIRO1
  • MIRO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.95
molecular function
0.95
histone modification site profile
0.85
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.9   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.9   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (224)
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.999868417
p_ni:  0.000131583
Score:  0.932
Data Source:  BioPlex,STRINGDB
RHOT2
Tbio
Family:  Enzyme
Novelty:  0.01712732
p_int:  0.998011044
p_ni:  0.001988956
Score:  0.919
Data Source:  BioPlex,STRINGDB
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.995867756
p_ni:  0.004132244
Score:  0.891
Data Source:  BioPlex,STRINGDB
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.856103153
p_ni:  0.143896847
Score:  0.393
Data Source:  BioPlex,STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.989
Data Source:  STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.963
Data Source:  STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.961
Data Source:  STRINGDB
TOMM70
Tbio
Novelty:  0.00943973
Score:  0.958
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.946
Data Source:  STRINGDB
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Rho GTPase cycle
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
17.8
red blood cell distribution width
1
1
1
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
17.8
red blood cell distribution width
1
17.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member T1
VGNC:9562
454570
Macaque
ras homolog family member T1
717901
Mouse
MGI:1926078
59040
Rat
RGD:1307023
303351
Dog
ras homolog family member T1
VGNC:45563
480613
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member T1
Macaque
ras homolog family member T1
Mouse
Rat
Dog
ras homolog family member T1
Publication Statistics
PubMed Score 87.90
PubMed score by year
PubTator Score 33.88
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title