Tbio RHOQ Rho-related GTP-binding protein RhoQ

Protein Summary

Description

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P17081
• D6W5A6
• Q0VGN1
• Q52LS8
• Q53SJ1
• Q6NS39
• Q6P146
• Q7Z480

Gene Name

• RHOQ

Ensembl ID

• ENST00000238738
• ENSP00000238738
• ENSG00000119729

Symbol

• ARHQ
• RASL7A
• TC10
• ARHQ
• TC10
• TC10A
• RASL7A
• HEL-S-42

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
molecular function	0.95
virus perturbation	0.9
biological process	0.82

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhoq

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhoq

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.51   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.51   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0