Tbio RHOF Rho-related GTP-binding protein RhoF

Protein Summary

Description

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Uniprot Accession IDs

• Q9HBH0
• Q8WVB1
• Q9NXH6

Gene Name

• RHOF

Ensembl ID

• ENST00000267205
• ENSP00000267205
• ENSG00000139725
• ENST00000537171
• ENSP00000477391

Symbol

• ARHF
• RIF
• RIF
• ARHF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
molecular function	0.9
interacting protein	0.77
PubMedID	0.7
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhof

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Gtp-binding Protein Rhof

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.51   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.51   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0