RHOF
Rho-related GTP-binding protein RhoF
Protein Summary
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
- ENST00000267205
- ENSP00000267205
- ENSG00000139725
- ENST00000537171
- ENSP00000477391
- ARHF
- RIF
- RIF
- ARHF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.98 | ||
molecular function | 0.9 | ||
interacting protein | 0.77 | ||
PubMedID | 0.7 | ||
tissue sample | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.94 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 222 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.94 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 222 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
TTC9C
Novelty: 0.85949913
p_int: 0.99970992
p_ni: 0.000011024
p_wrong: 0.000279055
Data Source: BioPlex
NAA25
Family: Enzyme
Novelty: 0.05422122
p_int: 0.998573728
p_ni: 0.000321515
p_wrong: 0.001104757
Score: 0.379
Data Source: BioPlex,STRINGDB
RAP1GDS1
Family: Enzyme
Novelty: 0.06140479
p_int: 0.985534299
p_ni: 0.014465701
Score: 0.221
Data Source: BioPlex,STRINGDB
CCT6B
Novelty: 0.28933315
p_int: 0.903758519
p_ni: 0.096241481
Score: 0.19
Data Source: BioPlex,STRINGDB
LY86
Novelty: 0.00314575
p_int: 0.89678532
p_ni: 0.000769594
p_wrong: 0.102445087
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Reactome | Rho GTPase cycle | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Rho GTPase cycle | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (3)
Components (9)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 7 | 4 | 9 | 99 | |||||
platelet crit | 2 | 2 | 4 | 95.8 | |||||
platelet count | 2 | 1 | 2 | 87.6 | |||||
reticulocyte measurement | 3 | 2 | 3 | 86.4 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 83.2 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 9 | 99 | |||||
platelet crit | 4 | 95.8 | |||||
platelet count | 2 | 87.6 | |||||
reticulocyte measurement | 3 | 86.4 | |||||
mean reticulocyte volume | 1 | 83.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ras homolog family member F, filopodia associated | VGNC:13437 | 465186 | |||||
Macaque | ras homolog family member F, filopodia associated | 703262 | ||||||
Mouse | MGI:1345629 | 23912 | ||||||
Rat | RGD:1584038 | 690130 | ||||||
Dog | ras homolog family member F, filopodia associated | VGNC:45559 | 610807 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ras homolog family member F, filopodia associated | |||||
Macaque | ras homolog family member F, filopodia associated | |||||
Mouse | ||||||
Rat | ||||||
Dog | ras homolog family member F, filopodia associated | |||||
Publication Statistics
PubMed Score 40.94
PubMed score by year
PubTator Score 241.38
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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