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Tbio
RHOF
Rho-related GTP-binding protein RhoF

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267205
  • ENSP00000267205
  • ENSG00000139725
  • ENST00000537171
  • ENSP00000477391

Symbol
  • ARHF
  • RIF
  • RIF
  • ARHF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
molecular function
0.9
interacting protein
0.77
PubMedID
0.7
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.94   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.94   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (221)
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.99970992
p_ni:  0.000011024
p_wrong:  0.000279055
Data Source:  BioPlex
NAA25
Tbio
Family:  Enzyme
Novelty:  0.05422122
p_int:  0.998573728
p_ni:  0.000321515
p_wrong:  0.001104757
Score:  0.379
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.985534299
p_ni:  0.014465701
Score:  0.221
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.903758519
p_ni:  0.096241481
Score:  0.19
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.89678532
p_ni:  0.000769594
p_wrong:  0.102445087
Data Source:  BioPlex
MCF2
Tbio
Novelty:  0.00345951
Score:  0.967
Data Source:  STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.967
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.965
Data Source:  STRINGDB
TIAM2
Tbio
Novelty:  0.02358532
Score:  0.964
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Rho GTPase cycle
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
4
9
99
platelet crit
2
2
4
95.8
platelet count
2
1
2
87.6
reticulocyte measurement
3
2
3
86.4
mean reticulocyte volume
1
1
1
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99
platelet crit
4
95.8
platelet count
2
87.6
reticulocyte measurement
3
86.4
mean reticulocyte volume
1
83.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member F, filopodia associated
VGNC:13437
465186
Macaque
ras homolog family member F, filopodia associated
703262
Mouse
MGI:1345629
23912
Rat
RGD:1584038
690130
Dog
ras homolog family member F, filopodia associated
VGNC:45559
610807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member F, filopodia associated
Macaque
ras homolog family member F, filopodia associated
Mouse
Rat
Dog
ras homolog family member F, filopodia associated
Publication Statistics
PubMed Score 40.94
PubMed score by year
PubTator Score 241.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title