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Tbio
RHOC
Rho-related GTP-binding protein RhoC

Protein Summary
Description
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285735
  • ENSP00000285735
  • ENSG00000155366
  • ENST00000339083
  • ENSP00000345236
  • ENST00000369632
  • ENSP00000358646
  • ENST00000369633
  • ENSP00000358647
  • ENST00000369637
  • ENSP00000358651
  • ENST00000369638
  • ENSP00000358652
  • ENST00000369642
  • ENSP00000358656

Symbol
  • ARH9
  • ARHC
  • H9
  • ARH9
  • ARHC
  • RHOH9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
PubMedID
0.87
transcription factor perturbation
0.84
disease perturbation
0.83
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.43   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.43   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (361)
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.999999999
Score:  0.985
Data Source:  BioPlex,STRINGDB
DAAM2
Tbio
Novelty:  0.07318127
p_int:  0.9999977
p_ni:  0.000001824
p_wrong:  4.75e-7
Score:  0.639
Data Source:  BioPlex,STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
p_int:  0.999983044
p_ni:  0.000016955
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
C1orf198
Tdark
Novelty:  3.89427313
p_int:  0.99997803
p_ni:  0.000021964
p_wrong:  6e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
DAAM1
Tbio
Novelty:  0.02143008
p_int:  0.999889614
p_ni:  0.000110386
Score:  0.771
Data Source:  BioPlex,STRINGDB
RTKN
Tbio
Novelty:  0.01044337
p_int:  0.999882857
p_ni:  0.000022504
p_wrong:  0.000094639
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
ARHGEF1
Tbio
Novelty:  0.00677208
p_int:  0.999864902
p_ni:  0.000135098
Score:  0.985
Data Source:  BioPlex,STRINGDB
ARHGEF12
Tchem
Novelty:  0.01365866
p_int:  0.99871162
p_ni:  0.00128838
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
DIAPH1
Tbio
Novelty:  0.0150259
p_int:  0.997557845
p_ni:  0.002442154
p_wrong:  1e-9
Score:  0.897
Data Source:  BioPlex,STRINGDB
ZMYM4
Tbio
Novelty:  0.08839944
p_int:  0.983936428
p_ni:  0.016063572
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
G alpha (12/13) signalling events
GPCR downstream signalling
RHO GTPase Effectors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
5
8
8.1
97.7
creatinine measurement
3
3
3
96.1
diastolic blood pressure
3
3
6
93.2
intraocular pressure measurement
2
3
3
89.3
testosterone measurement
4
2
3
6.4
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
8.1
97.7
creatinine measurement
3
96.1
diastolic blood pressure
6
93.2
intraocular pressure measurement
3
89.3
testosterone measurement
3
6.4
88.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member C
VGNC:1493
100612435
Mouse
MGI:106028
11853
Rat
RGD:1304965
295342
Dog
ras homolog family member C
483218
Horse
ras homolog family member C
VGNC:50866
100146263
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member C
Mouse
Rat
Dog
ras homolog family member C
Horse
ras homolog family member C
Publication Statistics
PubMed Score 495.43
PubMed score by year
PubTator Score 246.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title