Tbio RHOBTB1 Rho-related BTB domain-containing protein 1

Protein Summary

Description

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• O94844

Gene Name

• RHOBTB1

Ensembl ID

• ENST00000337910
• ENSP00000338671
• ENSG00000072422
• ENST00000357917
• ENSP00000350595

Symbol

• KIAA0740

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
PubMedID	0.83
molecular function	0.73
tissue sample	0.73
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Btb Domain-containing Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Rho-related Btb Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.51   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.51   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0