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Tbio
RHOBTB1
Rho-related BTB domain-containing protein 1

Protein Summary
Description
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337910
  • ENSP00000338671
  • ENSG00000072422
  • ENST00000357917
  • ENSP00000350595

Symbol
  • KIAA0740
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.83
molecular function
0.73
tissue sample
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.51   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.51   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
APBB3
Tbio
Novelty:  0.15864948
p_int:  1
Score:  0.625
Data Source:  BioPlex,STRINGDB
BPIFA2
Tbio
Novelty:  0.01533858
p_int:  0.99999716
p_ni:  0.000002813
p_wrong:  2.7e-8
Data Source:  BioPlex
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999948943
p_ni:  0.000045698
p_wrong:  0.000005359
Score:  0.183
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.999840319
p_ni:  0.000159681
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.999712574
p_ni:  0.00028739
p_wrong:  3.6e-8
Data Source:  BioPlex
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999159931
p_ni:  0.000840069
Score:  0.688
Data Source:  BioPlex,STRINGDB
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.999011775
p_ni:  0.000161671
p_wrong:  0.000826554
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.99886663
p_ni:  0.001133358
p_wrong:  1.2e-8
Data Source:  BioPlex
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.997165525
p_ni:  0.000257322
p_wrong:  0.002577152
Score:  0.561
Data Source:  BioPlex,STRINGDB
CST4
Tbio
Novelty:  0.00773554
p_int:  0.996585391
p_ni:  0.003414528
p_wrong:  8.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho related BTB domain containing 1
VGNC:7860
450482
Macaque
Rho related BTB domain containing 1
699132
Mouse
MGI:1916538
69288
Rat
RGD:1306871
309722
Dog
Rho related BTB domain containing 1
VGNC:45556
488998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho related BTB domain containing 1
Macaque
Rho related BTB domain containing 1
Mouse
Rat
Dog
Rho related BTB domain containing 1
Publication Statistics
PubMed Score 37.51
PubMed score by year
PubTator Score 3.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title