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Tbio
RHOB
Rho-related GTP-binding protein RhoB

Protein Summary
Description
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272233
  • ENSP00000272233
  • ENSG00000143878

Symbol
  • ARH6
  • ARHB
  • ARH6
  • ARHB
  • RHOH6
  • MST081
  • MSTP081
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
kinase perturbation
0.96
molecular function
0.93
small molecule perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.05   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.05   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (323)
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
p_int:  0.8724693
p_ni:  0.000015365
p_wrong:  0.127515335
Data Source:  BioPlex
ALG6
Tbio
Family:  Enzyme
Novelty:  0.02610188
p_int:  0.860317692
p_ni:  0.000099779
p_wrong:  0.139582529
Data Source:  BioPlex
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.991
Data Source:  STRINGDB
ARHGDIG
Tbio
Novelty:  0.11734153
Score:  0.989
Data Source:  STRINGDB
ARHGAP35
Tbio
Family:  Enzyme
Novelty:  0.00970784
Score:  0.987
Data Source:  STRINGDB
ARHGAP5
Tbio
Family:  Enzyme
Novelty:  0.03683127
Score:  0.983
Data Source:  STRINGDB
ARHGEF3
Tbio
Novelty:  0.02419137
Score:  0.982
Data Source:  STRINGDB
ARHGDIB
Tbio
Novelty:  0.01139758
Score:  0.98
Data Source:  STRINGDB
ARHGEF12
Tchem
Novelty:  0.01365866
Score:  0.979
Data Source:  Reactome,STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
Score:  0.978
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
GPVI-mediated activation cascade
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
G alpha (12/13) signalling events
GPCR downstream signalling
GPVI-mediated activation cascade
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HMG CoA reductase inhibitor use measurement
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HMG CoA reductase inhibitor use measurement
1
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107949
11852
Rat
RGD:621309
64373
Dog
ras homolog family member B
VGNC:45555
403670
Horse
ras homolog family member B
VGNC:22371
100056328
Cow
ras homolog family member B
VGNC:33944
515118
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ras homolog family member B
Horse
ras homolog family member B
Cow
ras homolog family member B
Publication Statistics
PubMed Score 551.05
PubMed score by year
PubTator Score 198.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title