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Tbio
RHOA
Transforming protein RhoA

Protein Summary
Description
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418115
  • ENSP00000400175
  • ENSG00000067560

Symbol
  • ARH12
  • ARHA
  • RHO12
  • ARHA
  • ARH12
  • RHO12
  • RHOH12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.99
pathway
0.99
biological process
0.98
interacting protein
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5165.41   (req: < 5)
Gene RIFs: 670   (req: <= 3)
Antibodies: 606   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5165.41   (req: >= 5)
Gene RIFs: 670   (req: > 3)
Antibodies: 606   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (888)
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
p_int:  0.999999999
Score:  0.985
Data Source:  BioPlex,STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
p_int:  0.999998384
p_ni:  0.000001615
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ARHGEF2
Tbio
Novelty:  0.01494954
p_int:  0.999951086
p_ni:  0.000048909
p_wrong:  6e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
ARHGEF1
Tbio
Novelty:  0.00677208
p_int:  0.999868839
p_ni:  0.000131155
p_wrong:  6e-9
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
ARHGEF12
Tchem
Novelty:  0.01365866
p_int:  0.999645165
p_ni:  0.000354835
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.999601735
p_ni:  0.000398265
Score:  0.966
Data Source:  BioPlex,STRINGDB
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.999470313
p_ni:  0.000529687
Score:  0.997
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999139374
p_ni:  0.000860626
Data Source:  BioPlex
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.9987404
p_ni:  0.001259409
p_wrong:  1.9e-7
Score:  0.95
Data Source:  BioPlex,Reactome,STRINGDB
PDCD2
Tbio
Novelty:  0.05054811
p_int:  0.996103087
p_ni:  0.003889213
p_wrong:  0.0000077
Data Source:  BioPlex
Nearest Tclin Targets (10)
Explore Nearest Tclin Targets
Pathways (189)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 58
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Axonal growth stimulation
Reactome
Beta-catenin independent WNT signaling
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Axon guidance
Axonal growth inhibition (RHOA activation)
Axonal growth stimulation
Beta-catenin independent WNT signaling
Death Receptor Signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (127)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
13
5
6.8
98
self reported educational attainment
5
4
4
1
97.3
3
4
4
91.8
educational attainment
2
5
3
104.5
90.7
red blood cell distribution width
4
3
4
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
6.8
98
self reported educational attainment
4
1
97.3
4
91.8
educational attainment
3
104.5
90.7
red blood cell distribution width
4
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member A
VGNC:12171
461014
Mouse
MGI:1096342
11848
Rat
RGD:619921
117273
Dog
ras homolog family member A
403954
Cow
ras homolog family member A
VGNC:33943
338049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member A
Mouse
Rat
Dog
ras homolog family member A
Cow
ras homolog family member A
Publication Statistics
PubMed Score 5165.41
PubMed score by year
PubTator Score 2218.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title