Protein Summary
Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017]
- ENST00000296271
- ENSP00000296271
- ENSG00000163914
- OPN2
- RP4
- OPN2
- CSNBAD1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
gene perturbation | 0.79 | ||
cell type or tissue | 0.74 | ||
molecular function | 0.73 | ||
biological term | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7737.99 (req: < 5)
Gene RIFs: 127 (req: <= 3)
Antibodies: 492 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7737.99 (req: >= 5)
Gene RIFs: 127 (req: > 3)
Antibodies: 492 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (293)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (23)
Reactome (16)
KEGG (1)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the phototransduction cascade | ||||
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the phototransduction cascade | ||||
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (4)
Components (13)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 13 | 21 | 39 | 98.8 | |||||
waist-hip ratio | 4 | 16 | 17 | 98.8 | |||||
BMI-adjusted hip circumference | 3 | 18 | 21 | 98.6 | |||||
hip circumference | 3 | 17 | 20 | 98 | |||||
waist circumference | 1 | 9 | 9 | 92.8 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 39 | 98.8 | |||||
waist-hip ratio | 17 | 98.8 | |||||
BMI-adjusted hip circumference | 21 | 98.6 | |||||
hip circumference | 20 | 98 | |||||
waist circumference | 9 | 92.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | rhodopsin | VGNC:2537 | 460685 | |||||
Mouse | MGI:97914 | 212541 | ||||||
Rat | RGD:3573 | 24717 | ||||||
Dog | rhodopsin | VGNC:45554 | 493763 | |||||
Horse | rhodopsin | VGNC:22370 | 100056641 | |||||
Publication Statistics
PubMed Score 7737.99
PubMed score by year
PubTator Score 3931.88
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (213)
GeneRif Annotations (127)
Items per page:
0 of 0
PMID | Year | Title |
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