Tbio RHNO1 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

Protein Summary

Description

Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.

Uniprot Accession IDs

• Q9BSD3
• B7Z989

Gene Name

• RHNO1

Ensembl ID

• ENST00000461997
• ENSP00000438828
• ENSG00000171792
• ENST00000489288
• ENSP00000438590
• ENST00000618250
• ENSP00000479598

Symbol

• C12orf32
• RHINO
• RHINO
• C12orf32
• HKMT1188

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
transcription factor perturbation	0.74
cell line	0.67
cell type or tissue	0.67
tissue	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 3   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0