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Tbio
RHNO1
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

Protein Summary
Description
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000461997
  • ENSP00000438828
  • ENSG00000171792
  • ENST00000489288
  • ENSP00000438590
  • ENST00000618250
  • ENSP00000479598

Symbol
  • C12orf32
  • RHINO
  • RHINO
  • C12orf32
  • HKMT1188
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor perturbation
0.74
cell line
0.67
cell type or tissue
0.67
tissue
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 3   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.969
Data Source:  STRINGDB
TOPBP1
Tbio
Family:  Enzyme
Novelty:  0.00735579
Score:  0.96
Data Source:  STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
Score:  0.958
Data Source:  STRINGDB
HUS1
Tbio
Novelty:  0.00837493
Score:  0.955
Data Source:  STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
Score:  0.939
Data Source:  STRINGDB
ATRIP
Tbio
Novelty:  0.01415267
Score:  0.937
Data Source:  STRINGDB
RAD1
Tchem
Novelty:  0.0060275
Score:  0.93
Data Source:  STRINGDB
RFC2
Tbio
Novelty:  0.02088405
Score:  0.927
Data Source:  STRINGDB
RAD17
Tbio
Novelty:  0.00640979
Score:  0.923
Data Source:  STRINGDB
TIPIN
Tbio
Novelty:  0.03919376
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
8
2
7
2
97.4
sex hormone-binding globulin measurement
4
1
4
78.9
estradiol measurement
1
1
1
77.4
vital capacity
1
1
1
65.5
mean corpuscular volume
1
1
1
59.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
2
97.4
sex hormone-binding globulin measurement
4
78.9
estradiol measurement
1
77.4
vital capacity
1
65.5
mean corpuscular volume
1
59.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD9-HUS1-RAD1 interacting nuclear orphan 1
VGNC:8523
451752
Mouse
MGI:1915315
72440
Rat
RGD:1359404
297627
Dog
RAD9-HUS1-RAD1 interacting nuclear orphan 1
VGNC:45553
100682990
Horse
RAD9-HUS1-RAD1 interacting nuclear orphan 1
VGNC:22369
100050852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD9-HUS1-RAD1 interacting nuclear orphan 1
Mouse
Rat
Dog
RAD9-HUS1-RAD1 interacting nuclear orphan 1
Horse
RAD9-HUS1-RAD1 interacting nuclear orphan 1
Publication Statistics
PubMed Score 7.68
PubMed score by year
PubTator Score 3.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title