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Tbio
RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

Protein Summary
Description
Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331555
  • ENSP00000356093
  • ENSG00000263961
  • ENST00000582070
  • ENSP00000463990
  • ENST00000603488
  • ENSP00000474994

Symbol
  • C1orf186
  • C1orf186
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
WDR47
Tdark
Novelty:  0.51632776
p_int:  0.999999995
p_ni:  5e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
p_int:  0.999193869
p_ni:  0.000805976
p_wrong:  1.55e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.997612005
p_ni:  0.002387311
p_wrong:  6.84e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
p_int:  0.958809322
p_ni:  0.041190674
p_wrong:  3e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.952047232
p_ni:  0.047946288
p_wrong:  0.00000648
Data Source:  BioPlex
NOS1AP
Tbio
Family:  Enzyme
Novelty:  0.0076555
p_int:  0.948604543
p_ni:  0.051352505
p_wrong:  0.000042951
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.913478871
p_ni:  0.086521087
p_wrong:  4.3e-8
Data Source:  BioPlex
DYNLL1
Tbio
Novelty:  0.00397334
p_int:  0.902347606
p_ni:  0.097652394
Score:  0.209
Data Source:  BioPlex,STRINGDB
JPH1
Tbio
Novelty:  0.00931679
p_int:  0.869997622
p_ni:  0.130002377
p_wrong:  1e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of hemoglobinization and erythroid cell expansion
VGNC:11739
743678
Macaque
regulator of hemoglobinization and erythroid cell expansion
696291
Dog
regulator of hemoglobinization and erythroid cell expansion
VGNC:49593
607341
Horse
regulator of hemoglobinization and erythroid cell expansion
VGNC:50451
100055210
Cow
regulator of hemoglobinization and erythroid cell expansion
VGNC:49539
616928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of hemoglobinization and erythroid cell expansion
Macaque
regulator of hemoglobinization and erythroid cell expansion
Dog
regulator of hemoglobinization and erythroid cell expansion
Horse
regulator of hemoglobinization and erythroid cell expansion
Cow
regulator of hemoglobinization and erythroid cell expansion
Publication Statistics
PubMed Score 4.88
PubMed score by year
PubTator Score 6.53
PubTator score by year
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Related Publications
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PMID
Year
Title