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Tdark
RHBDL1
Rhomboid-related protein 1

Protein Summary
Description
May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219551
  • ENSP00000219551
  • ENSG00000103269
  • ENST00000352681
  • ENSP00000344206

Symbol
  • RHBDL
  • RRP
  • RHBDL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
protein domain
0.58
tissue sample
0.55
cell line
0.51
disease perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.96   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.96   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
MAGI3
Tbio
Family:  Enzyme
Novelty:  0.03968945
p_int:  0.999999689
p_ni:  3.11e-7
Score:  0.561
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999960618
p_ni:  0.000039374
p_wrong:  8e-9
Score:  0.489
Data Source:  BioPlex,STRINGDB
MAGI2
Tbio
Family:  Enzyme
Novelty:  0.01674725
p_int:  0.976936011
p_ni:  4.6e-8
p_wrong:  0.023063943
Score:  0.696
Data Source:  BioPlex,STRINGDB
ITGB8
Tbio
Novelty:  0.01564348
p_int:  0.83790173
p_ni:  0.162000162
p_wrong:  0.000098108
Score:  0.216
Data Source:  BioPlex,STRINGDB
PARL
Tbio
Family:  Enzyme
Novelty:  0.01317944
Score:  0.827
Data Source:  STRINGDB
RHBDF1
Tbio
Family:  Enzyme
Novelty:  0.01942693
Score:  0.786
Data Source:  STRINGDB
RHBDF2
Tbio
Family:  Enzyme
Novelty:  0.02487334
Score:  0.78
Data Source:  STRINGDB
RHBDD2
Tbio
Family:  Enzyme
Novelty:  0.17415558
Score:  0.635
Data Source:  STRINGDB
UTS2R
Tchem
Family:  GPCR
Novelty:  0.00865846
Score:  0.62
Data Source:  STRINGDB
RHBDD1
Tbio
Family:  Enzyme
Novelty:  0.10354568
Score:  0.613
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
11
91.8
mean corpuscular volume
1
1
1
84
BMI-adjusted waist circumference
1
7
7
82.8
mean reticulocyte volume
1
2
2
81.8
cancer antigen 125 measurement
1
3
3
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
91.8
mean corpuscular volume
1
84
BMI-adjusted waist circumference
7
82.8
mean reticulocyte volume
2
81.8
cancer antigen 125 measurement
3
77.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhomboid like 1
VGNC:10360
453801
Macaque
rhomboid like 1
722357
Mouse
MGI:2384891
214951
Rat
RGD:620699
117025
Dog
rhomboid like 1
VGNC:45548
490092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhomboid like 1
Macaque
rhomboid like 1
Mouse
Rat
Dog
rhomboid like 1
Publication Statistics
PubMed Score 0.96
PubMed score by year
PubTator Score 9.00
PubTator score by year
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Related Publications
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PMID
Year
Title