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Tbio
RHBDF1
Inactive rhomboid protein 1

Protein Summary
Description
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262316
  • ENSP00000262316
  • ENSG00000007384

Symbol
  • C16orf8
  • DIST1
  • IRHOM1
  • Dist1
  • hDist1
  • C16orf8
  • EGFR-RS
  • gene-89
  • gene-90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
histone modification site profile
0.67
tissue sample
0.64
cellular component
0.62
transcription factor
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.87   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.87   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.99999725
p_ni:  1e-9
p_wrong:  0.000002749
Score:  0.27
Data Source:  BioPlex,STRINGDB
DCXR
Tbio
Family:  Enzyme
Novelty:  0.00967328
Score:  0.902
Data Source:  STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
Score:  0.858
Data Source:  STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
Score:  0.836
Data Source:  STRINGDB
SNRNP25
Tdark
Novelty:  0.5951307
Score:  0.83
Data Source:  STRINGDB
RHBDL1
Tdark
Family:  Enzyme
Novelty:  0.63616927
Score:  0.786
Data Source:  STRINGDB
MGRN1
Tbio
Family:  Enzyme
Novelty:  0.04981605
Score:  0.763
Data Source:  STRINGDB
PARL
Tchem
Family:  Enzyme
Novelty:  0.01317944
Score:  0.733
Data Source:  STRINGDB
RHBDD2
Tbio
Family:  Enzyme
Novelty:  0.17415558
Score:  0.72
Data Source:  STRINGDB
AQP8
Tbio
Novelty:  0.00613662
Score:  0.708
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
6
8
9
98.9
erythrocyte count
5
6
7
97.4
mean corpuscular hemoglobin
2
3
3
96.3
hemoglobin measurement
4
5
7
94.9
reticulocyte count
7
10
23
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
9
98.9
erythrocyte count
7
97.4
mean corpuscular hemoglobin
3
96.3
hemoglobin measurement
7
94.9
reticulocyte count
23
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhomboid 5 homolog 1
VGNC:10359
453783
Mouse
MGI:104328
13650
Rat
RGD:1305075
303008
Dog
rhomboid 5 homolog 1
VGNC:45546
490101
Horse
rhomboid 5 homolog 1
VGNC:22362
100066340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhomboid 5 homolog 1
Mouse
Rat
Dog
rhomboid 5 homolog 1
Horse
rhomboid 5 homolog 1
Publication Statistics
PubMed Score 78.87
PubMed score by year
PubTator Score 15.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title