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Tbio
RHBDD3
Rhomboid domain-containing protein 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216085
  • ENSP00000216085
  • ENSG00000100263

Symbol
  • C22orf3
  • PTAG
  • C22orf3
  • HS984G1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.75
tissue sample
0.73
transcription factor
0.63
cell line
0.58
biological process
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.997287656
p_ni:  0.002712201
p_wrong:  1.43e-7
Data Source:  BioPlex
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.992760234
p_ni:  0.00723976
p_wrong:  6e-9
Data Source:  BioPlex
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.992678976
p_ni:  0.007321006
p_wrong:  1.8e-8
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.991082908
p_ni:  0.00764361
p_wrong:  0.001273482
Score:  0.2
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.977148961
p_ni:  0.022608879
p_wrong:  0.00024216
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.969978422
p_ni:  0.02962902
p_wrong:  0.000392558
Data Source:  BioPlex
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.966933179
p_ni:  0.032838231
p_wrong:  0.00022859
Score:  0.159
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.955045779
p_ni:  0.04443777
p_wrong:  0.000516452
Score:  0.313
Data Source:  BioPlex,STRINGDB
FNDC5
Tbio
Novelty:  0.0015827
p_int:  0.946152517
p_ni:  0.053327949
p_wrong:  0.000519534
Score:  0.189
Data Source:  BioPlex,STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.94083357
p_ni:  0.057089473
p_wrong:  0.002076957
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
8
92.5
monocyte count
2
2
2
89.4
heel bone mineral density
2
2
2
89
reticulocyte measurement
2
2
4
88.3
mean platelet volume
3
2
3
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
8
92.5
monocyte count
2
89.4
heel bone mineral density
2
89
reticulocyte measurement
4
88.3
mean platelet volume
3
86.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhomboid domain containing 3
VGNC:53404
458739
Macaque
rhomboid domain containing 3
714479
Mouse
MGI:2444684
279766
Rat
RGD:1311827
289753
Dog
rhomboid domain containing 3
VGNC:45545
486341
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhomboid domain containing 3
Macaque
rhomboid domain containing 3
Mouse
Rat
Dog
rhomboid domain containing 3
Publication Statistics
PubMed Score 23.47
PubMed score by year
PubTator Score 32.09
PubTator score by year
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Related Publications
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PMID
Year
Title