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Tbio
RHBDD1
Rhomboid-related protein 4

Protein Summary
Description
Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341329
  • ENSP00000344779
  • ENSG00000144468
  • ENST00000392062
  • ENSP00000375914

Symbol
  • RHBDL4
  • RRP4
  • RHBDL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.95
histone modification site profile
0.81
cellular component
0.68
transcription factor binding site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.18   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.18   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999811572
p_ni:  0.000188427
p_wrong:  2e-9
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.998420671
p_ni:  0.001490764
p_wrong:  0.000088565
Data Source:  BioPlex
RNF5
Tbio
Family:  Enzyme
Novelty:  0.03015609
p_int:  0.995495641
p_ni:  0.004496993
p_wrong:  0.000007365
Score:  0.185
Data Source:  BioPlex,STRINGDB
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
p_int:  0.993431267
p_ni:  0.006566157
p_wrong:  0.000002576
Data Source:  BioPlex
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.981030118
p_ni:  0.016127021
p_wrong:  0.002842861
Score:  0.2
Data Source:  BioPlex,STRINGDB
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.937598212
p_ni:  0.059551463
p_wrong:  0.002850325
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.932219211
p_ni:  0.058821993
p_wrong:  0.008958796
Data Source:  BioPlex
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
p_int:  0.910128202
p_ni:  0.088156222
p_wrong:  0.001715577
Data Source:  BioPlex
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.90430754
p_ni:  0.094437428
p_wrong:  0.001255031
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.898303818
p_ni:  0.101033195
p_wrong:  0.000662988
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary microalbumin measurement
1
1
1
90.7
urinary albumin to creatinine ratio
3
3
3
78
appendicular lean mass
2
1
2
72.3
reticulocyte measurement
2
1
2
55.5
albuminuria
2
1
2
49.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary microalbumin measurement
1
90.7
urinary albumin to creatinine ratio
3
78
appendicular lean mass
2
72.3
reticulocyte measurement
2
55.5
albuminuria
2
49.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhomboid domain containing 1
VGNC:2802
100608035
Macaque
rhomboid domain containing 1
707982
Mouse
MGI:1924117
76867
Rat
RGD:1306477
316557
Dog
rhomboid domain containing 1
VGNC:45543
486149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhomboid domain containing 1
Macaque
rhomboid domain containing 1
Mouse
Rat
Dog
rhomboid domain containing 1
Publication Statistics
PubMed Score 19.18
PubMed score by year
PubTator Score 9.02
PubTator score by year
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Related Publications
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PMID
Year
Title