You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RGS9BP
Regulator of G-protein signaling 9-binding protein

Protein Summary
Description
Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334176
  • ENSP00000334134
  • ENSG00000186326

Symbol
  • R9AP
  • R9AP
  • RGS9
  • PERRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
cell type or tissue
0.76
gene perturbation
0.65
cell line
0.6
transcription factor binding site profile
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
RGS9
Tbio
Novelty:  0.06662559
Score:  0.985
Data Source:  Reactome,STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.979
Data Source:  Reactome,STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.948
Data Source:  STRINGDB
PDE6A
Tclin
Family:  Enzyme
Novelty:  0.02680494
Score:  0.94
Data Source:  STRINGDB
PDE6C
Tclin
Family:  Enzyme
Novelty:  0.02239368
Score:  0.939
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.938
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.934
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.927
Data Source:  STRINGDB
PDE6G
Tclin
Family:  Enzyme
Novelty:  0.03113994
Score:  0.923
Data Source:  STRINGDB
RGS11
Tbio
Novelty:  0.02181028
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
6
96
mean platelet volume
3
1
3
82.4
mean corpuscular volume
1
2
2
81
mean reticulocyte volume
1
2
2
74
hemoglobin measurement
1
1
1
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
96
mean platelet volume
3
82.4
mean corpuscular volume
2
81
mean reticulocyte volume
2
74
hemoglobin measurement
1
73.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384418
243923
Rat
RGD:1561747
499132
Dog
regulator of G protein signaling 9 binding protein
VGNC:45540
612699
Cow
regulator of G protein signaling 9 binding protein
VGNC:33927
282338
Opossum
regulator of G protein signaling 9 binding protein
100011926
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
regulator of G protein signaling 9 binding protein
Cow
regulator of G protein signaling 9 binding protein
Opossum
regulator of G protein signaling 9 binding protein
Publication Statistics
PubMed Score 26.81
PubMed score by year
PubTator Score 9.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title