Tbio RGS5 Regulator of G-protein signaling 5

Protein Summary

Description

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• O15539
• E9PMP5
• Q53XA9
• Q599J0
• RGS5

Gene Name

• RGS5

Ensembl ID

• ENST00000313961
• ENSP00000319308
• ENSG00000143248
• ENST00000527988
• ENSP00000432313
• ENST00000530507
• ENSP00000433001
• ENST00000618415
• ENSP00000480891

Symbol

• MST092
• MST106
• MST129
• MSTP032
• MSTP092
• MSTP106
• MSTP129

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.84
small molecule perturbation	0.82
gene perturbation	0.81
histone modification site profile	0.81
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 5

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.95   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 347   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.95   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0