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Tbio
RGS14
Regulator of G-protein signaling 14

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resista ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408923
  • ENSP00000386229
  • ENSG00000169220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
molecular function
0.88
disease perturbation
0.87
kinase perturbation
0.76
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.12   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.12   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999999215
p_ni:  2.38e-7
p_wrong:  5.46e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.996610103
p_ni:  2.2e-8
p_wrong:  0.003389875
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.983
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.967
Data Source:  STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.929
Data Source:  STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
Score:  0.91
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.82
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.813
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.813
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.812
Data Source:  STRINGDB
Nearest Tclin Targets (21)
Explore Nearest Tclin Targets
1 – 5 of 18
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  1
CSF1R
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  1
KIT
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  1
EPHA2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  1
KDR
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  1
Pathways (14)
G alpha (i) signalling events (R-HSA-418594)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
9
12
15.2
99.4
creatinine measurement
5
7
8
97.1
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
12
15.2
99.4
creatinine measurement
8
97.1
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 14
VGNC:8634
471758
Macaque
regulator of G protein signaling 14
699625
Mouse
MGI:1859709
51791
Rat
RGD:620003
114705
Dog
regulator of G protein signaling 14
VGNC:45524
489092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 14
Macaque
regulator of G protein signaling 14
Mouse
Rat
Dog
regulator of G protein signaling 14
Publication Statistics
PubMed Score 60.12
PubMed score by year
PubTator Score 29.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title