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Tbio
RGP1
RAB6A-GEF complex partner protein 2

Protein Summary
Description
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378078
  • ENSP00000367318
  • ENSG00000107185

Symbol
  • KIAA0258
  • KIAA0258
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.62
cell line
0.61
tissue sample
0.55
transcription factor binding site profile
0.55
small molecule perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
GTSF1
Tbio
Novelty:  0.13243562
p_int:  0.99999641
p_ni:  0.000002422
p_wrong:  0.000001168
Score:  0.485
Data Source:  BioPlex,STRINGDB
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.998358472
p_ni:  0.000562303
p_wrong:  0.001079225
Score:  0.169
Data Source:  BioPlex,STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
p_int:  0.8947732
p_ni:  1.8e-8
p_wrong:  0.105226782
Score:  0.485
Data Source:  BioPlex,STRINGDB
RIC1
Tbio
Novelty:  0.04422709
Score:  0.986
Data Source:  Reactome,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
Score:  0.955
Data Source:  STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.955
Data Source:  Reactome,STRINGDB
VPS52
Tbio
Novelty:  0.01439614
Score:  0.953
Data Source:  STRINGDB
VPS54
Tbio
Novelty:  0.04428383
Score:  0.943
Data Source:  STRINGDB
VPS53
Tbio
Novelty:  0.07513165
Score:  0.943
Data Source:  STRINGDB
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
Score:  0.927
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
74.8
lymphocyte count
2
1
2
74.4
leukocyte count
1
1
1
68.6
red blood cell distribution width
1
1
1
64
body height
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
74.8
lymphocyte count
2
74.4
leukocyte count
1
68.6
red blood cell distribution width
1
64
body height
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RGP1 homolog, RAB6A GEF complex partner 1
VGNC:4847
465083
Mouse
MGI:1915956
242406
Rat
RGD:1311757
313493
Dog
RGP1 homolog, RAB6A GEF complex partner 1
VGNC:45517
100684169
Horse
RGP1 homolog, RAB6A GEF complex partner 1
VGNC:22337
100067753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RGP1 homolog, RAB6A GEF complex partner 1
Mouse
Rat
Dog
RGP1 homolog, RAB6A GEF complex partner 1
Horse
RGP1 homolog, RAB6A GEF complex partner 1
Publication Statistics
PubMed Score 0.38
PubMed score by year
PubTator Score 2.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title