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Tbio
RGN
Regucalcin

Protein Summary
Description
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336169
  • ENSP00000338400
  • ENSG00000130988
  • ENST00000352078
  • ENSP00000253303
  • ENST00000397180
  • ENSP00000380365
  • ENST00000457380
  • ENSP00000406568

Symbol
  • SMP30
  • RC
  • GNL
  • SMP30
  • HEL-S-41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease
0.63
phenotype
0.62
chemical
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.49   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.49   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.966615952
p_ni:  0.000005627
p_wrong:  0.033378421
Score:  0.219
Data Source:  BioPlex,STRINGDB
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.826972725
p_ni:  3.7e-8
p_wrong:  0.173027238
Score:  0.228
Data Source:  BioPlex,STRINGDB
IDNK
Tbio
Family:  Kinase
Novelty:  0.07579524
Score:  0.944
Data Source:  STRINGDB
SEC16B
Tbio
Novelty:  0.04073621
Score:  0.939
Data Source:  STRINGDB
SEC16A
Tbio
Novelty:  0.02221416
Score:  0.834
Data Source:  STRINGDB
H6PD
Tbio
Novelty:  0.00366637
Score:  0.709
Data Source:  STRINGDB
FAAH2
Tchem
Family:  Enzyme
Novelty:  0.06197067
Score:  0.685
Data Source:  STRINGDB
SORD
Tchem
Family:  Enzyme
Novelty:  0.0040485
Score:  0.62
Data Source:  STRINGDB
ENOSF1
Tbio
Family:  Enzyme
Novelty:  0.05583478
Score:  0.614
Data Source:  STRINGDB
HSPE1
Tbio
Novelty:  0.00074376
Score:  0.591
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Carbon metabolism
KEGG
Metabolic pathways
KEGG
Ascorbate and aldarate metabolism
KEGG
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Carbon metabolism
Metabolic pathways
Ascorbate and aldarate metabolism
Pentose phosphate pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total blood protein measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total blood protein measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regucalcin
107970955
Macaque
regucalcin
705733
Mouse
MGI:108024
19733
Rat
RGD:3560
25106
Dog
regucalcin
VGNC:45516
480893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regucalcin
Macaque
regucalcin
Mouse
Rat
Dog
regucalcin
Publication Statistics
PubMed Score 657.49
PubMed score by year
PubTator Score 84.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title