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Tbio
RGMA
Repulsive guidance molecule A

Protein Summary
Description
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329082
  • ENSP00000330005
  • ENSG00000182175
  • ENST00000425933
  • ENSP00000404442
  • ENST00000542321
  • ENSP00000440025
  • ENST00000543599
  • ENSP00000442498

Symbol
  • RGM
  • RGM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
transcription factor binding site profile
0.73
cell type or tissue
0.72
tissue
0.69
transcription factor
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.67   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.67   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
BMP2
Tbio
Novelty:  0.00016974
Score:  0.997
Data Source:  STRINGDB
NEO1
Tbio
Novelty:  0.00625858
Score:  0.995
Data Source:  Reactome,STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.981
Data Source:  STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.932
Data Source:  STRINGDB
BAMBI
Tbio
Novelty:  0.00736806
Score:  0.931
Data Source:  STRINGDB
CHRD
Tbio
Novelty:  0.00347659
Score:  0.926
Data Source:  STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
Score:  0.923
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.923
Data Source:  STRINGDB
NOG
Tbio
Novelty:  0.0010373
Score:  0.922
Data Source:  STRINGDB
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Netrin-1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
67.9
heel bone mineral density
2
2
2
65.7
cognitive function measurement
1
1
1
40.7
mean corpuscular volume
1
1
1
40.7
creatinine measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
67.9
heel bone mineral density
2
65.7
cognitive function measurement
1
40.7
mean corpuscular volume
1
40.7
creatinine measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
repulsive guidance molecule BMP co-receptor a
VGNC:1890
453667
Macaque
repulsive guidance molecule family member a
712949
Mouse
MGI:2679262
244058
Rat
RGD:1311983
308739
Dog
repulsive guidance molecule BMP co-receptor a
VGNC:45515
100856151
Species
Name
OMA
EggNOG
Inparanoid
Chimp
repulsive guidance molecule BMP co-receptor a
Macaque
repulsive guidance molecule family member a
Mouse
Rat
Dog
repulsive guidance molecule BMP co-receptor a
Publication Statistics
PubMed Score 211.67
PubMed score by year
PubTator Score 55.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title