Protein Summary
This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]
- ENST00000290691
- ENSP00000290691
- ENSG00000159496
- RGR
- Rgr
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.65 | ||
cell type or tissue | 0.63 | ||
cell line | 0.5 | ||
cellular component | 0.44 | ||
tissue | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.06 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.06 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
DCX
Novelty: 0.00077614
p_int: 0.972499343
p_ni: 0.027498235
p_wrong: 0.000002422
Score: 0.359
Data Source: BioPlex,STRINGDB
OCIAD1
Novelty: 0.05701069
p_int: 0.894824158
p_ni: 0.105175841
p_wrong: 1e-9
Score: 0.513
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GPCRs, Class A Rhodopsin-like | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (1)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum IgG glycosylation measurement | 1 | 1 | 1 | 82.8 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 48.5 | |||||
lymphocyte count | 1 | 1 | 1 | 39.6 | |||||
body height | 1 | 1 | 1 | 26.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum IgG glycosylation measurement | 1 | 82.8 | |||||
serum non-albumin protein measurement | 1 | 48.5 | |||||
lymphocyte count | 1 | 39.6 | |||||
body height | 1 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ral-GDS-related protein [Source:RefSeq peptide;Acc:NP_001267349] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ral-GDS-related protein [Source:RefSeq peptide;Acc:NP_001267349] | |||||
Publication Statistics
PubMed Score 4.06
PubMed score by year
PubTator Score 1.06
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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