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Tdark
RGL4
Ral-GDS-related protein

Protein Summary
Description
This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290691
  • ENSP00000290691
  • ENSG00000159496

Symbol
  • RGR
  • Rgr
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
cell type or tissue
0.63
cell line
0.5
cellular component
0.44
tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.06   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.06   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
DCX
Tbio
Novelty:  0.00077614
p_int:  0.972499343
p_ni:  0.027498235
p_wrong:  0.000002422
Score:  0.359
Data Source:  BioPlex,STRINGDB
OCIAD1
Tbio
Novelty:  0.05701069
p_int:  0.894824158
p_ni:  0.105175841
p_wrong:  1e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.834
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.722
Data Source:  STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.646
Data Source:  STRINGDB
LRRC75B
Tdark
Novelty:  2.22222222
Score:  0.644
Data Source:  STRINGDB
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
Score:  0.643
Data Source:  STRINGDB
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.643
Data Source:  STRINGDB
C12orf49
Tdark
Novelty:  0.56030929
Score:  0.63
Data Source:  STRINGDB
REM1
Tbio
Family:  Enzyme
Novelty:  0.00407925
Score:  0.626
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
1
1
1
82.8
serum non-albumin protein measurement
1
1
1
48.5
lymphocyte count
1
1
1
39.6
body height
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
1
82.8
serum non-albumin protein measurement
1
48.5
lymphocyte count
1
39.6
body height
1
26.6
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ral-GDS-related protein [Source:RefSeq peptide;Acc:NP_001267349]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ral-GDS-related protein [Source:RefSeq peptide;Acc:NP_001267349]
Publication Statistics
PubMed Score 4.06
PubMed score by year
PubTator Score 1.06
PubTator score by year
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Related Publications
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PMID
Year
Title