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Tbio
RGL2
Ral guanine nucleotide dissociation stimulator-like 2

Protein Summary
Description
Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383204
  • ENSP00000372691
  • ENSG00000206282
  • ENST00000413136
  • ENSP00000407088
  • ENSG00000224841
  • ENST00000416548
  • ENSP00000412152
  • ENSG00000228736
  • ENST00000452084
  • ENSP00000390098
  • ENSG00000237825
  • ENST00000497454
  • ENSP00000420211
  • ENSG00000237441

Symbol
  • RAB2L
  • KE1.5
  • RAB2L
  • HKE1.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
protein domain
0.85
transcription factor binding site profile
0.77
histone modification site profile
0.69
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0