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Tbio
RGL1
Ral guanine nucleotide dissociation stimulator-like 1

Protein Summary
Description
Probable guanine nucleotide exchange factor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304685
  • ENSP00000303192
  • ENSG00000143344
  • ENST00000360851
  • ENSP00000354097

Symbol
  • KIAA0959
  • RGL
  • RGL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
microRNA
0.9
protein domain
0.85
transcription factor
0.85
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.31   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.31   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.999998931
p_ni:  0.000001069
Score:  0.448
Data Source:  BioPlex,STRINGDB
ATL2
Tbio
Novelty:  0.03633884
p_int:  0.999944819
p_ni:  0.000055176
p_wrong:  4e-9
Data Source:  BioPlex
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
p_int:  0.994434569
p_ni:  0.005149088
p_wrong:  0.000416343
Score:  0.486
Data Source:  BioPlex,STRINGDB
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.9936165
p_ni:  0.006383405
p_wrong:  9.5e-8
Data Source:  BioPlex
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
p_int:  0.992725058
p_ni:  0.007274634
p_wrong:  3.08e-7
Score:  0.92
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.992532424
p_ni:  0.007165967
p_wrong:  0.000301609
Score:  0.948
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.988158857
p_ni:  0.001293655
p_wrong:  0.010547488
Data Source:  BioPlex
RRAS2
Tbio
Family:  Enzyme
Novelty:  0.01870067
p_int:  0.960530839
p_ni:  0.039469161
Score:  0.895
Data Source:  BioPlex,STRINGDB
LENG8
Tdark
Novelty:  0.66682078
p_int:  0.817054466
p_ni:  0.182854507
p_wrong:  0.000091028
Data Source:  BioPlex
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
Score:  0.936
Data Source:  STRINGDB
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
2
97.2
reticulocyte count
6
4
6
90
reticulocyte measurement
3
2
3
82.9
aspartate aminotransferase measurement
2
1
1
12.3
81.2
BMI-adjusted hip circumference
2
4
4
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
97.2
reticulocyte count
6
90
reticulocyte measurement
3
82.9
aspartate aminotransferase measurement
1
12.3
81.2
BMI-adjusted hip circumference
4
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ral guanine nucleotide dissociation stimulator like 1
VGNC:11878
457575
Macaque
ral guanine nucleotide dissociation stimulator like 1
717554
Mouse
MGI:107484
19731
Rat
RGD:1308947
289080
Dog
ral guanine nucleotide dissociation stimulator like 1
VGNC:45512
480038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ral guanine nucleotide dissociation stimulator like 1
Macaque
ral guanine nucleotide dissociation stimulator like 1
Mouse
Rat
Dog
ral guanine nucleotide dissociation stimulator like 1
Publication Statistics
PubMed Score 104.31
PubMed score by year
PubTator Score 28.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title