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Tbio
RGCC
Regulator of cell cycle RGCC

Protein Summary
Description
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379359
  • ENSP00000368664
  • ENSG00000102760

Symbol
  • C13orf15
  • RGC32
  • RGC32
  • RGC-32
  • C13orf15
  • bA157L14.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
1
small molecule perturbation
0.94
ligand (protein) perturbation
0.83
PubMedID
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.72   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.72   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
TLN2
Tbio
Novelty:  0.0284423
p_int:  0.999999811
p_ni:  1.82e-7
p_wrong:  7e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
CARS2
Tbio
Family:  Enzyme
Novelty:  0.0105933
p_int:  0.999724253
p_ni:  0.000004955
p_wrong:  0.000270793
Score:  0.513
Data Source:  BioPlex,STRINGDB
TLN1
Tbio
Novelty:  0.00803981
p_int:  0.992598098
p_ni:  0.007401902
Score:  0.534
Data Source:  BioPlex,STRINGDB
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.790258849
p_ni:  0.164823332
p_wrong:  0.044917819
Score:  0.2
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.963
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.832
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.826
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.737
Data Source:  STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.69
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Cycle Genes
Reactome
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Cycle Genes
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
65.6
heel bone mineral density
2
2
2
61.3
systolic blood pressure
1
1
1
12.7
balding measurement
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
65.6
heel bone mineral density
2
61.3
systolic blood pressure
1
12.7
balding measurement
1
5.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of cell cycle
VGNC:51889
749634
Macaque
regulator of cell cycle
698962
Mouse
MGI:1913464
66214
Rat
RGD:619721
117183
Cow
regulator of cell cycle
VGNC:33902
614348
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of cell cycle
Macaque
regulator of cell cycle
Mouse
Rat
Cow
regulator of cell cycle
Publication Statistics
PubMed Score 61.72
PubMed score by year
PubTator Score 34.57
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title