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Tbio
RFXANK
DNA-binding protein RFXANK

Protein Summary
Description
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity). Isoform 2 is not involved in the positive regulation of MHC class II genes. Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303088
  • ENSP00000305071
  • ENSG00000064490
  • ENST00000407360
  • ENSP00000384572
  • ENST00000456252
  • ENSP00000409138

Symbol
  • ANKRA1
  • RFXB
  • BLS
  • RFX-B
  • ANKRA1
  • F14150_1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
tissue sample
0.62
cell line
0.55
biological process
0.54
interacting protein
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.84   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.84   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
RFX5
Tbio
Family:  TF
Novelty:  0.02002111
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
p_int:  0.999980123
p_ni:  0.000019877
Score:  0.352
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.996599446
p_ni:  0.001325541
p_wrong:  0.002075012
Score:  0.199
Data Source:  BioPlex,STRINGDB
C5orf34
Tdark
Novelty:  1.01063928
p_int:  0.915907431
p_ni:  0.081119465
p_wrong:  0.002973104
Data Source:  BioPlex
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.890048501
p_ni:  0.109951499
Score:  0.182
Data Source:  BioPlex,STRINGDB
HAUS5
Tbio
Novelty:  0.99720546
p_int:  0.875521931
p_ni:  0.124478069
Score:  0.26
Data Source:  BioPlex,STRINGDB
N4BP2L2
Tbio
Novelty:  0.24527466
p_int:  0.86008029
p_ni:  0.136388074
p_wrong:  0.003531635
Score:  0.181
Data Source:  BioPlex,STRINGDB
SMARCA1
Tbio
Novelty:  0.00452148
p_int:  0.818940334
p_ni:  0.181059666
Score:  0.278
Data Source:  BioPlex,STRINGDB
HDAC4
Tclin
Family:  Epigenetic
Novelty:  0.00217749
Score:  0.997
Data Source:  STRINGDB
RFX7
Tdark
Family:  TF
Novelty:  0.15609316
Score:  0.989
Data Source:  STRINGDB
Pathways (5)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Tuberculosis
KEGG
Primary immunodeficiency
KEGG
Antigen processing and presentation
Name
Explore in Pharos
Explore in Source
Tuberculosis
Primary immunodeficiency
Antigen processing and presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
12
9
17
3
99.7
triglyceride measurement
15
6
22
8.2
99.2
total cholesterol measurement
9
4
11
4.4
98.8
apolipoprotein B measurement
2
4
4
98.5
serum alanine aminotransferase measurement
3
3
3
17.9
97.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
17
3
99.7
triglyceride measurement
22
8.2
99.2
total cholesterol measurement
11
4.4
98.8
apolipoprotein B measurement
4
98.5
serum alanine aminotransferase measurement
3
17.9
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X associated ankyrin containing protein
VGNC:7572
455872
Macaque
regulatory factor X associated ankyrin containing protein
719706
Mouse
MGI:1333865
19727
Rat
RGD:1311390
306353
Dog
regulatory factor X associated ankyrin containing protein
VGNC:45511
476662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X associated ankyrin containing protein
Macaque
regulatory factor X associated ankyrin containing protein
Mouse
Rat
Dog
regulatory factor X associated ankyrin containing protein
Publication Statistics
PubMed Score 278.84
PubMed score by year
PubTator Score 31.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title