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Tbio
RFX6
DNA-binding protein RFX6

Protein Summary
Description
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100). The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332958
  • ENSP00000332208
  • ENSG00000185002

Symbol
  • RFXDC1
  • MTFS
  • MTCHRS
  • RFXDC1
  • dJ955L16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.73
molecular function
0.73
histone modification site profile
0.53
cell type or tissue
0.46
microRNA
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.81   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.81   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
INS
Tbio
Novelty:  0.00000499
Score:  0.968
Data Source:  STRINGDB
MTFMT
Tbio
Family:  Enzyme
Novelty:  0.011101
Score:  0.8
Data Source:  STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
Score:  0.8
Data Source:  STRINGDB
DTX2
Tbio
Family:  Enzyme
Novelty:  0.01981892
Score:  0.791
Data Source:  STRINGDB
SS18L1
Tbio
Novelty:  0.10255799
Score:  0.768
Data Source:  STRINGDB
RFXANK
Tbio
Novelty:  0.00355465
Score:  0.765
Data Source:  STRINGDB
CCNK
Tbio
Novelty:  0.03528971
Score:  0.753
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.744
Data Source:  STRINGDB
PAX4
Tbio
Family:  TF
Novelty:  0.00697085
Score:  0.723
Data Source:  STRINGDB
NKX6-1
Tbio
Family:  TF
Novelty:  0.00776559
Score:  0.688
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
0
1.2
79.3
glucose measurement
1
1
1
60.2
eosinophil count
2
2
2
59
apolipoprotein A 1 measurement
1
1
1
50.6
1
1
0
1.1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
79.3
glucose measurement
1
60.2
eosinophil count
2
59
apolipoprotein A 1 measurement
1
50.6
0
1.1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X6
VGNC:7907
472210
Macaque
regulatory factor X6
715469
Mouse
MGI:2445208
320995
Rat
RGD:1307491
294395
Dog
regulatory factor X6
VGNC:45508
484096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X6
Macaque
regulatory factor X6
Mouse
Rat
Dog
regulatory factor X6
Publication Statistics
PubMed Score 38.81
PubMed score by year
PubTator Score 22.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title