Tbio RFX6 DNA-binding protein RFX6

Protein Summary

Description

Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100). The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q8HWS3
• Q5T6B3

Gene Name

• RFX6

Ensembl ID

• ENST00000332958
• ENSP00000332208
• ENSG00000185002

Symbol

• RFXDC1
• MTFS
• MTCHRS
• RFXDC1
• dJ955L16.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.73
molecular function	0.73
histone modification site profile	0.53
cell type or tissue	0.46
microRNA	0.44

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dna-binding Protein Rfx6

Protein / ... / Winged Helix/forkhead Transcription Factor / Dna-binding Protein Rfx6

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Dna-binding Protein Rfx6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.93   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.93   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0