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Tbio
RFX5
DNA-binding protein RFX5

Protein Summary
Description
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290524
  • ENSP00000290524
  • ENSG00000143390
  • ENST00000368870
  • ENSP00000357864
  • ENST00000452671
  • ENSP00000389130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.9
histone modification site profile
0.88
protein complex
0.86
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.25   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.25   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
RFXANK
Tbio
Novelty:  0.00355465
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
RFX7
Tdark
Family:  TF
Novelty:  0.15609316
p_int:  1
Score:  0.779
Data Source:  BioPlex,STRINGDB
RFXAP
Tbio
Novelty:  0.04422686
p_int:  0.999999999
Score:  0.998
Data Source:  BioPlex,STRINGDB
ANKRA2
Tbio
Novelty:  0.19358401
p_int:  0.981557841
p_wrong:  0.018442159
Score:  0.9
Data Source:  BioPlex,STRINGDB
CSTF2T
Tbio
Novelty:  0.11811814
p_int:  0.915672317
p_ni:  0.08432768
p_wrong:  3e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
CIITA
Tbio
Novelty:  0.00245662
Score:  0.992
Data Source:  STRINGDB
RBMS1
Tbio
Novelty:  0.00520684
Score:  0.823
Data Source:  STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
Score:  0.768
Data Source:  STRINGDB
CCDC82
Tdark
Novelty:  0.48211191
Score:  0.725
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.697
Data Source:  STRINGDB
Pathways (4)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Tuberculosis
KEGG
Primary immunodeficiency
KEGG
Antigen processing and presentation
Name
Explore in Pharos
Explore in Source
Tuberculosis
Primary immunodeficiency
Antigen processing and presentation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
66.8
lymphocyte count
1
1
1
29
gut microbiome measurement
1
1
0
5.6
21.5
BMI-adjusted hip circumference
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
66.8
lymphocyte count
1
29
gut microbiome measurement
0
5.6
21.5
BMI-adjusted hip circumference
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X5
VGNC:6978
457292
Mouse
MGI:1858421
53970
Rat
RGD:1311677
310659
Dog
regulatory factor X5
VGNC:45507
483197
Horse
regulatory factor X5
VGNC:22329
100055472
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X5
Mouse
Rat
Dog
regulatory factor X5
Horse
regulatory factor X5
Publication Statistics
PubMed Score 50.25
PubMed score by year
PubTator Score 43.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title