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Tbio
RFX3
Transcription factor RFX3

Protein Summary
Description
Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302303
  • ENSP00000303847
  • ENSG00000080298
  • ENST00000358730
  • ENSP00000351574
  • ENST00000382004
  • ENSP00000371434
  • ENST00000617270
  • ENSP00000482598
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
transcription factor binding site profile
0.91
histone modification site profile
0.88
transcription factor
0.85
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
p_int:  0.999999997
p_ni:  3e-9
Score:  0.4
Data Source:  BioPlex,STRINGDB
RFX2
Tbio
Family:  TF
Novelty:  0.04660141
p_int:  0.999999995
p_wrong:  5e-9
Data Source:  BioPlex
FOXJ1
Tbio
Family:  TF
Novelty:  0.00778536
p_int:  0.999999949
p_ni:  9e-9
p_wrong:  4.2e-8
Score:  0.932
Data Source:  BioPlex,STRINGDB
FOXN3
Tbio
Family:  TF
Novelty:  0.02908033
p_int:  0.999999926
p_ni:  7.3e-8
p_wrong:  1e-9
Score:  0.287
Data Source:  BioPlex,STRINGDB
PABPC5
Tdark
Novelty:  0.36077159
p_int:  0.999954469
p_ni:  0.000045522
p_wrong:  9e-9
Score:  0.695
Data Source:  BioPlex,STRINGDB
MTCH2
Tbio
Novelty:  0.01794294
p_int:  0.991130875
p_ni:  0.008869122
p_wrong:  3e-9
Data Source:  BioPlex
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.923026777
p_ni:  0.076973222
Score:  0.19
Data Source:  BioPlex,STRINGDB
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.896332907
p_ni:  0.103666842
p_wrong:  2.51e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
Score:  0.865
Data Source:  STRINGDB
DTX2
Tbio
Family:  Enzyme
Novelty:  0.01981892
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
69.4
type 2 diabetes mellitus
1
1
1
15.1
antisocial behaviour measurement
1
1
1
14.8
1
1
1
14.8
substance abuse
1
1
1
14.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
69.4
type 2 diabetes mellitus
1
15.1
antisocial behaviour measurement
1
14.8
1
14.8
substance abuse
1
14.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
regulatory factor X3
695861
Mouse
MGI:106582
19726
Dog
regulatory factor X3
VGNC:45505
476339
Horse
regulatory factor X3
VGNC:22328
100051128
Cow
regulatory factor X3
VGNC:33895
538070
Species
Name
OMA
EggNOG
Inparanoid
Macaque
regulatory factor X3
Mouse
Dog
regulatory factor X3
Horse
regulatory factor X3
Cow
regulatory factor X3
Publication Statistics
PubMed Score 22.88
PubMed score by year
PubTator Score 8.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title