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Tbio
RFX1
MHC class II regulatory factor RFX1

Protein Summary
Description
Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254325
  • ENSP00000254325
  • ENSG00000132005

Symbol
  • EFC
  • RFX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
disease perturbation
0.79
hub protein
0.79
histone modification site profile
0.76
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.97   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.97   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
RFX3
Tbio
Family:  TF
Novelty:  0.04646733
p_int:  0.999999997
p_ni:  3e-9
Score:  0.4
Data Source:  BioPlex,STRINGDB
FOXJ1
Tbio
Family:  TF
Novelty:  0.00778536
p_int:  0.99999995
p_ni:  5e-8
Score:  0.687
Data Source:  BioPlex,STRINGDB
FOXN2
Tbio
Family:  TF
Novelty:  0.06019241
p_int:  0.999999373
p_ni:  6.27e-7
Score:  0.304
Data Source:  BioPlex,STRINGDB
FOXN3
Tbio
Family:  TF
Novelty:  0.02908033
p_int:  0.999998823
p_ni:  0.000001176
p_wrong:  1e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
FBXL3
Tbio
Novelty:  0.05042679
p_int:  0.999951937
p_ni:  0.000048063
Score:  0.546
Data Source:  BioPlex,STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.999398822
p_ni:  0.000601178
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.999073749
p_ni:  0.000926241
p_wrong:  1.1e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.985239931
p_ni:  0.014760069
Data Source:  BioPlex
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
p_int:  0.971025744
p_ni:  0.028972899
p_wrong:  0.000001357
Data Source:  BioPlex
HSPB8
Tbio
Novelty:  0.00298618
p_int:  0.881702498
p_ni:  0.118180189
p_wrong:  0.000117313
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
62.1
lymphocyte count
1
1
1
58.4
reticulocyte count
2
2
2
56.6
lymphocyte percentage of leukocytes
1
1
1
53.7
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
62.1
lymphocyte count
1
58.4
reticulocyte count
2
56.6
lymphocyte percentage of leukocytes
1
53.7
1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X1
VGNC:6650
468746
Macaque
regulatory factor X1
718526
Mouse
MGI:105982
19724
Rat
RGD:1306574
288906
Dog
regulatory factor X1
VGNC:45503
484908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulatory factor X1
Macaque
regulatory factor X1
Mouse
Rat
Dog
regulatory factor X1
Publication Statistics
PubMed Score 406.97
PubMed score by year
PubTator Score 144.13
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title