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Tbio
RFWD3
E3 ubiquitin-protein ligase RFWD3

Protein Summary
Description
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361070
  • ENSP00000354361
  • ENSG00000168411
  • ENST00000571750
  • ENSP00000460049

Symbol
  • RNF201
  • FANCW
  • RNF201
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.85
virus perturbation
0.85
microRNA
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.71   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.71   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.9999972
p_ni:  0.0000028
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999992686
p_ni:  0.000007314
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999914404
p_ni:  0.000079606
p_wrong:  0.00000599
Data Source:  BioPlex
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999842571
p_ni:  0.000157416
p_wrong:  1.3e-8
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999796575
p_ni:  0.000203424
p_wrong:  1e-9
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999213222
p_ni:  0.000546776
p_wrong:  0.000240002
Data Source:  BioPlex
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999183081
p_ni:  0.000816919
Data Source:  BioPlex
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.997995444
p_ni:  0.002004551
p_wrong:  5e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.997782222
p_ni:  0.002217618
p_wrong:  1.6e-7
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.990276509
p_ni:  0.007266879
p_wrong:  0.002456612
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (52)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
83.2
monocyte percentage of leukocytes
2
1
2
80.5
neutrophil percentage of leukocytes
1
1
1
66.3
granulocyte percentage of myeloid white cells
1
1
1
64.4
monocyte count
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
83.2
monocyte percentage of leukocytes
2
80.5
neutrophil percentage of leukocytes
1
66.3
granulocyte percentage of myeloid white cells
1
64.4
monocyte count
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger and WD repeat domain 3
VGNC:5908
454242
Macaque
ring finger and WD repeat domain 3
710227
Mouse
MGI:2384584
234736
Dog
ring finger and WD repeat domain 3
VGNC:45502
610424
Horse
ring finger and WD repeat domain 3
VGNC:22325
100055114
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger and WD repeat domain 3
Macaque
ring finger and WD repeat domain 3
Mouse
Dog
ring finger and WD repeat domain 3
Horse
ring finger and WD repeat domain 3
Publication Statistics
PubMed Score 16.71
PubMed score by year
PubTator Score 4.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title