Tbio RFFL E3 ubiquitin-protein ligase rififylin

Protein Summary

Description

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.

Uniprot Accession IDs

• Q8WZ73
• E1P633
• Q8NHW0
• Q8TBY7
• Q96BE6

Gene Name

• RFFL

Ensembl ID

• ENST00000315249
• ENSP00000326170
• ENSG00000092871
• ENST00000394597
• ENSP00000378096
• ENST00000413582
• ENSP00000408513
• ENST00000415395
• ENSP00000412322
• ENST00000447669
• ENSP00000389832
• ENST00000584655
• ENSP00000463035

Symbol

• RNF189
• RNF34L
• CARP2
• FRING
• CARP-2
• RNF189
• RNF34L
• RIFIFYLIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
transcription factor binding site profile	0.85
transcription factor perturbation	0.84
biological process	0.81
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rififylin

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rififylin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.17   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 239   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.17   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0