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Tbio
REXO4
RNA exonuclease 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371935
  • ENSP00000361003
  • ENSG00000148300
  • ENST00000371942
  • ENSP00000361010
  • ENST00000628678
  • ENSP00000487504
  • ENSG00000280706
  • ENST00000630460
  • ENSP00000486065

Symbol
  • PMC2
  • XPMC2H
  • REX4
  • XPMC2
  • XPMC2H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
histone modification site profile
0.8
kinase perturbation
0.76
cell type or tissue
0.66
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
RBM28
Tbio
Novelty:  0.13090674
p_int:  0.999432554
p_ni:  0.000567446
Score:  0.786
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.983185147
p_ni:  0.016814853
Score:  0.813
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.980883645
p_ni:  0.019116355
Score:  0.24
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.980151462
p_ni:  0.019848538
Score:  0.269
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.978994877
p_ni:  0.021005123
Score:  0.159
Data Source:  BioPlex,STRINGDB
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.974412816
p_ni:  0.025587184
Score:  0.306
Data Source:  BioPlex,STRINGDB
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.973857288
p_ni:  0.026142712
Score:  0.265
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.95998753
p_ni:  0.04001247
Score:  0.717
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.95773066
p_ni:  0.04226934
Data Source:  BioPlex
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.954629293
p_ni:  0.045370707
Score:  0.724
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
5
5
96.8
total cholesterol measurement
1
5
5
96.8
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
3
0
7.1
96.4
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
3
0
7.1
96.4
low density lipoprotein cholesterol measurement
1
4
4
95.7
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
5
96.8
total cholesterol measurement
5
96.8
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
7.1
96.4
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
7.1
96.4
low density lipoprotein cholesterol measurement
4
95.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
REX4 homolog, 3'-5' exonuclease
VGNC:53291
473152
Macaque
REX4 homolog, 3'-5' exonuclease
713816
Mouse
MGI:2684957
227656
Rat
RGD:1306220
311826
Dog
REX4 homolog, 3'-5' exonuclease
VGNC:45491
491271
Species
Name
OMA
EggNOG
Inparanoid
Chimp
REX4 homolog, 3'-5' exonuclease
Macaque
REX4 homolog, 3'-5' exonuclease
Mouse
Rat
Dog
REX4 homolog, 3'-5' exonuclease
Publication Statistics
PubMed Score 35.71
PubMed score by year
PubTator Score 3.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title