Tbio REXO4 RNA exonuclease 4

Protein Summary

Uniprot Accession IDs

• Q9GZR2
• B2RAT2
• Q5T8S4
• Q5T8S5
• Q5T8S6
• Q9GZW3

Gene Name

• REXO4

Ensembl ID

• ENST00000371935
• ENSP00000361003
• ENSG00000148300
• ENST00000371942
• ENSP00000361010
• ENST00000628678
• ENSP00000487504
• ENSG00000280706
• ENST00000630460
• ENSP00000486065

Symbol

• PMC2
• XPMC2H
• REX4
• XPMC2
• XPMC2H

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.86
histone modification site profile	0.8
kinase perturbation	0.76
cell type or tissue	0.66
tissue sample	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (137)

Explore Interacting Targets

1 – 10 of 137

• See Interactions on String-DB

RBM28

Tbio

Novelty:  0.13090674

p_int:  0.999432554

p_ni:  0.000567446

Score:  0.786

Data Source:  BioPlex,STRINGDB

RRP8

Tbio

Family:  Enzyme

Novelty:  0.04922797

p_int:  0.983185147

p_ni:  0.016814853

Score:  0.813

Data Source:  BioPlex,STRINGDB

RPL18

Tbio

Novelty:  0.01765545

p_int:  0.980883645

p_ni:  0.019116355

Score:  0.24

Data Source:  BioPlex,STRINGDB

RPL30

Tbio

Novelty:  0.0134194

p_int:  0.980151462

p_ni:  0.019848538

Score:  0.269

Data Source:  BioPlex,STRINGDB

RBM4

Tbio

Novelty:  0.02034191

p_int:  0.978994877

p_ni:  0.021005123

Score:  0.159

Data Source:  BioPlex,STRINGDB

NPM1

Tbio

Novelty:  0.0005485

p_int:  0.974412816

p_ni:  0.025587184

Score:  0.306

Data Source:  BioPlex,STRINGDB

RPL14

Tbio

Novelty:  0.01600377

p_int:  0.973857288

p_ni:  0.026142712

Score:  0.265

Data Source:  BioPlex,STRINGDB

RBM34

Tdark

Novelty:  0.58131282

p_int:  0.95998753

p_ni:  0.04001247

Score:  0.717

Data Source:  BioPlex,STRINGDB

H2AFY2

Tbio

Novelty:  0.09948698

p_int:  0.95773066

p_ni:  0.04226934

Data Source:  BioPlex

PPAN

Tbio

Novelty:  0.01063709

p_int:  0.954629293

p_ni:  0.045370707

Score:  0.724

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (3)

Components (3)

Processes (2)

Find Similar Targets

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
DNA-binding transcription factor activity	Non-traceable Author Statement (NAS)	UniProtKB
3'-5' exonuclease activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (28)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
total cholesterol measurement	EFO_0004574	ENSG00000148300	1	5	5		96.8
total cholesterol measurement	EFO_0004574	ENSG00000280706	1	5	5		96.8
a disintegrin and metalloproteinase with thrombospondin motifs 13	EFO_0008011	ENSG00000148300	1	3	0	7.1	96.4
a disintegrin and metalloproteinase with thrombospondin motifs 13	EFO_0008011	ENSG00000280706	1	3	0	7.1	96.4
low density lipoprotein cholesterol measurement	EFO_0004611	ENSG00000148300	1	4	4		95.7

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
total cholesterol measurement	EFO_0004574	5		96.8
total cholesterol measurement	EFO_0004574	5		96.8
a disintegrin and metalloproteinase with thrombospondin motifs 13	EFO_0008011	0	7.1	96.4
a disintegrin and metalloproteinase with thrombospondin motifs 13	EFO_0008011	0	7.1	96.4
low density lipoprotein cholesterol measurement	EFO_0004611	4		95.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Exonuclease
Hydrolase
Isopeptide bond
Nuclease
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
a disintegrin and metalloproteinase with thrombospondin motifs 13
ADAMTS13 activity measurement
angiopoietin-1 receptor measurement
apolipoprotein B measurement
e-selectin measurement
glucose measurement
HbA1c measurement
liver enzyme measurement
low density lipoprotein cholesterol measurement
lymphocyte percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	REX4 homolog, 3'-5' exonuclease	VGNC:53291	473152
Macaque	REX4 homolog, 3'-5' exonuclease		713816
Mouse	REX4, 3'-5' exonuclease	MGI:2684957	227656
Rat	REX4 homolog, 3'-5' exonuclease	RGD:1306220	311826
Dog	REX4 homolog, 3'-5' exonuclease	VGNC:45491	491271

Species	Name	OMA	EggNOG	Inparanoid
Chimp	REX4 homolog, 3'-5' exonuclease
Macaque	REX4 homolog, 3'-5' exonuclease
Mouse	REX4, 3'-5' exonuclease
Rat	REX4 homolog, 3'-5' exonuclease
Dog	REX4 homolog, 3'-5' exonuclease

Publication Statistics

PubMed Score 35.71

PubMed score by year

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PubTator Score 3.24

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title