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Tbio
REXO2
Oligoribonuclease, mitochondrial

Protein Summary
Description
3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling. This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265881
  • ENSP00000265881
  • ENSG00000076043
  • ENST00000611665
  • ENSP00000480535

Symbol
  • SFN
  • SMFN
  • RFN
  • SFN
  • REX2
  • CGI-114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.99
disease perturbation
0.93
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.49   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.49   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
REXO1
Tdark
Family:  Enzyme
Novelty:  0.23817911
Score:  0.964
Data Source:  STRINGDB
REXO5
Tdark
Family:  Enzyme
Novelty:  0.8782494
Score:  0.904
Data Source:  STRINGDB
REXO4
Tbio
Family:  Enzyme
Novelty:  0.0328295
Score:  0.83
Data Source:  STRINGDB
NHP2
Tbio
Novelty:  0.01414024
Score:  0.789
Data Source:  STRINGDB
EXO1
Tbio
Family:  Enzyme
Novelty:  0.00130104
Score:  0.764
Data Source:  STRINGDB
ELAC2
Tbio
Family:  Enzyme
Novelty:  0.01234318
Score:  0.754
Data Source:  STRINGDB
SSBP1
Tbio
Novelty:  0.01105839
Score:  0.747
Data Source:  STRINGDB
LRFN3
Tdark
Novelty:  0.30018245
Score:  0.703
Data Source:  STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.702
Data Source:  STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.688
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
51.6
blood protein measurement
1
1
1
27.4
1
1
0
1.1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
51.6
blood protein measurement
1
27.4
0
1.1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA exonuclease 2
VGNC:1025
451561
Macaque
RNA exonuclease 2
695292
Mouse
MGI:1888981
104444
Rat
RGD:1304874
300689
Dog
RNA exonuclease 2
VGNC:45490
489395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA exonuclease 2
Macaque
RNA exonuclease 2
Mouse
Rat
Dog
RNA exonuclease 2
Publication Statistics
PubMed Score 98.49
PubMed score by year
PubTator Score 262.64
PubTator score by year
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Related Publications
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PMID
Year
Title