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Tdark
RETREG3
Reticulophagy regulator 3

Protein Summary
Description
Mediates NRF1-enhanced neurite outgrowth.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309428
  • ENSP00000309432
  • ENSG00000141699

Symbol
  • FAM134C
  • FAM134C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.999985566
p_ni:  0.000014052
p_wrong:  3.83e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
ATP9A
Tbio
Family:  Transporter
Novelty:  0.15755352
p_int:  0.999651559
p_ni:  0.000348432
p_wrong:  9e-9
Score:  0.516
Data Source:  BioPlex,STRINGDB
CD63
Tchem
Novelty:  0.00072515
p_int:  0.999358995
p_ni:  0.000583267
p_wrong:  0.000057738
Score:  0.185
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.998364333
p_ni:  0.001635667
Data Source:  BioPlex
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.997841907
p_ni:  0.002158093
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.996704075
p_ni:  0.003295925
Data Source:  BioPlex
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
p_int:  0.994044696
p_ni:  0.005948286
p_wrong:  0.000007018
Data Source:  BioPlex
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
p_int:  0.99259571
p_ni:  0.00740429
Data Source:  BioPlex
RNF170
Tbio
Family:  Enzyme
Novelty:  0.1117879
p_int:  0.991426541
p_ni:  0.008573459
Score:  0.525
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.990168603
p_ni:  0.009831396
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
4
2
1
94.5
sex hormone-binding globulin measurement
5
3
5
85.2
neuroimaging measurement
6
3
6
84.2
triglyceride measurement
4
3
4
82.4
high density lipoprotein cholesterol measurement
3
3
3
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1
94.5
sex hormone-binding globulin measurement
5
85.2
neuroimaging measurement
6
84.2
triglyceride measurement
4
82.4
high density lipoprotein cholesterol measurement
3
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reticulophagy regulator family member 3
VGNC:10364
741874
Macaque
reticulophagy regulator family member 3
710852
Mouse
MGI:1915248
67998
Rat
RGD:1561189
360632
Dog
reticulophagy regulator family member 3
VGNC:45485
490964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reticulophagy regulator family member 3
Macaque
reticulophagy regulator family member 3
Mouse
Rat
Dog
reticulophagy regulator family member 3
Publication Statistics
PubMed Score 2.19
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title