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Tdark
RETREG2
Reticulophagy regulator 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000430297
  • ENSP00000395249
  • ENSG00000144567

Symbol
  • C2orf17
  • FAM134A
  • MAG2
  • MAG-2
  • C2orf17
  • FAM134A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.8   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999992948
p_ni:  0.000007032
p_wrong:  2e-8
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.999956811
p_ni:  0.00004318
p_wrong:  9e-9
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.999905429
p_ni:  0.000083037
p_wrong:  0.000011534
Data Source:  BioPlex
ZDHHC11
Tdark
Family:  Enzyme
Novelty:  0.35249931
p_int:  0.999659126
p_ni:  0.000234098
p_wrong:  0.000106776
Score:  0.188
Data Source:  BioPlex,STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
p_int:  0.999561034
p_ni:  0.000284243
p_wrong:  0.000154723
Score:  0.173
Data Source:  BioPlex,STRINGDB
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.862918182
p_ni:  0.004707572
p_wrong:  0.132374247
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.82116539
p_ni:  0.005150898
p_wrong:  0.173683712
Data Source:  BioPlex
GPR52
Tchem
Family:  GPCR
Novelty:  0.07988639
p_int:  0.775212625
p_ni:  0.004762385
p_wrong:  0.220024991
Score:  0.189
Data Source:  BioPlex,STRINGDB
DPY19L4
Tdark
Family:  Enzyme
Novelty:  0.99997412
Score:  0.683
Data Source:  STRINGDB
CNPPD1
Tdark
Novelty:  1.33885532
Score:  0.629
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
4
5
96.6
reticulocyte count
4
2
6
92.8
reticulocyte measurement
3
2
5
92.7
vitamin C measurement
1
1
1
79.9
red blood cell distribution width
2
1
2
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
96.6
reticulocyte count
6
92.8
reticulocyte measurement
5
92.7
vitamin C measurement
1
79.9
red blood cell distribution width
2
75.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reticulophagy regulator family member 2
VGNC:1944
459958
Macaque
reticulophagy regulator family member 2
704378
Mouse
MGI:2388278
227298
Rat
RGD:1306844
363252
Dog
reticulophagy regulator family member 2
VGNC:45484
488535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reticulophagy regulator family member 2
Macaque
reticulophagy regulator family member 2
Mouse
Rat
Dog
reticulophagy regulator family member 2
Publication Statistics
PubMed Score 4.80
PubMed score by year
PubTator Score 20.08
PubTator score by year
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Related Publications
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PMID
Year
Title