Protein Summary
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
- ENST00000221515
- ENSP00000221515
- ENSG00000104918
- ENST00000381324
- ENSP00000370725
- ENST00000629642
- ENSP00000485998
- FIZZ3
- HXCP1
- RSTN
- ADSF
- RSTN
- XCP1
- FIZZ3
- RETN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
gene perturbation | 0.99 | ||
cell type or tissue | 0.77 | ||
biological process | 0.67 | ||
chemical | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1920.77 (req: < 5)
Gene RIFs: 589 (req: <= 3)
Antibodies: 814 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1920.77 (req: >= 5)
Gene RIFs: 589 (req: > 3)
Antibodies: 814 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0