Protein Summary
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
- ENST00000221515
- ENSP00000221515
- ENSG00000104918
- ENST00000381324
- ENSP00000370725
- ENST00000629642
- ENSP00000485998
- FIZZ3
- HXCP1
- RSTN
- ADSF
- RSTN
- XCP1
- FIZZ3
- RETN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
gene perturbation | 0.99 | ||
cell type or tissue | 0.77 | ||
biological process | 0.67 | ||
chemical | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1773.01 (req: < 5)
Gene RIFs: 489 (req: <= 3)
Antibodies: 814 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1773.01 (req: >= 5)
Gene RIFs: 489 (req: > 3)
Antibodies: 814 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (274)
GLI4
Family: TF
Novelty: 0.15339473
p_int: 0.999994028
p_ni: 7.07e-7
p_wrong: 0.000005265
Score: 0.359
Data Source: BioPlex,STRINGDB
SQSTM1
Novelty: 0.00100555
p_int: 0.997093079
p_ni: 0.002906921
Score: 0.187
Data Source: BioPlex,STRINGDB
APEX2
Family: Enzyme
Novelty: 0.04076395
p_int: 0.997045071
p_ni: 0.002953497
p_wrong: 0.000001432
Score: 0.209
Data Source: BioPlex,STRINGDB
ZNF664
Family: TF
Novelty: 0.25879878
p_int: 0.981509585
p_ni: 0.000142567
p_wrong: 0.018347848
Score: 0.313
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00043424
p_int: 0.926814004
p_ni: 0.073185996
Score: 0.244
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (8)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (1)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 3 | 4 | 93.1 | |||||
resistin measurement | 1 | 2 | 0 | 6.2 | 91.1 | ||||
leukocyte count | 1 | 3 | 3 | 89.1 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 9.5 | 73.9 | ||||
von Willebrand factor measurement | 1 | 1 | 2 | 65.5 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 4 | 93.1 | |||||
resistin measurement | 0 | 6.2 | 91.1 | ||||
leukocyte count | 3 | 89.1 | |||||
aspartate aminotransferase measurement | 0 | 9.5 | 73.9 | ||||
von Willebrand factor measurement | 2 | 65.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | resistin | VGNC:12073 | 742100 | |||||
Mouse | MGI:1888506 | 57264 | ||||||
Rat | RGD:628781 | 246250 | ||||||
Dog | resistin | VGNC:45482 | 611540 | |||||
Cow | resistin | VGNC:33877 | 369020 | |||||
Publication Statistics
PubMed Score 1773.01
PubMed score by year
PubTator Score 603.17
PubTator score by year
Related Publications
Text Mined References (534)
GeneRif Annotations (489)
Items per page:
0 of 0
PMID | Year | Title |
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